HitPredict

Interactor 1: UBP14 (P54578)
Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14)
Gene: USP14

Interactor 2: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.77 1.00 0.881

The method score is based on:

Property Details
Experiments 30425250, 31901637, 19615732, 17646385
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Prot_ATP_ID_OB~UCH
Common GO terms GO:0000502 - proteasome complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0031410 - cytoplasmic vesicle
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
and 1 others

more...
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 494
Hs

1 406
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024