HitPredict

Interactor 1: UBP14 (P54578)
Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14)
Gene: USP14

Interactor 2: PSMD2 (Q13200)
26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2)
Gene: PSMD2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.752

Property	Details
Experiments	28539385, 29581427, 29777785, 35271311, 30425250, 31901637, 31740976, 19615732, 24951540
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 494 Hs			1 908
+	Sp
		953208 UBP6_SCHPO (3-485): 1.47e-112: 342: 36.31		RPN1_SCHPO (8-905): 0: 1025: 47.67
+	Hs
		870881 UBP14_HUMAN (1-494): 7.04e-147: 431: 100.00		PSMD1_HUMAN (59-845): 0: 790: 17.31
+	Zm
		17878 A0A1D6JSI9_MAIZE (93-456): 4.4e-30: 126: 18.60		A0A1D6H0T6_MAIZE (45-906): 0: 1040: 51.88
+	Sc
		753859 UBP6_YEAST (4-481): 1.15e-88: 282: 30.10		RPN1_YEAST (49-906): 0: 869: 37.71
+	Sc
		753884 UBP8_YEAST (105-485): 5.83e-38: 146: 20.51		RPN1_YEAST (49-906): 0: 869: 37.71
+	Sp
		251851 UBP6_SCHPO (3-485): 1.47e-112: 342: 36.31		RPN2_SCHPO (59-844): 0: 667: 16.61
+	Sc
		693324 UBP6_YEAST (4-481): 1.15e-88: 282: 30.10		RPN2_YEAST (59-841): 0: 679: 17.83
+	Sc
		693331 UBP8_YEAST (105-485): 5.83e-38: 146: 20.51		RPN2_YEAST (59-841): 0: 679: 17.83