HitPredict

Interactor 1: AAKG1 (P54619)
5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg)
Gene: PRKAG1

Interactor 2: AAPK1 (Q13131)
5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
Gene: PRKAA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.989

The method score is based on:

Property Details
Experiments 8621713, 8663446, 26186194, 28514442, 31900314, 33961781, 10698692, 20562859, 25416956, 25852190, 34073624, 35271311, 32707033, 36736316, 16306228, 21232561, 23455922, 22363791, 31515488
Identification Methods pull down, affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, validated two hybrid, tandem affinity purification
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains AdenylateSensor~CBS
Common GO terms GO:0004672 - protein kinase activity
GO:0004691 - cAMP-dependent protein kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 8 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 331
Hs

1 559
+ Rn
+ Mm
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+ Hs
+ Hs
+ Hs
+ At
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+ Sp
+ Zm
+ Sp
+ At
+ Sc
+ Sc
+ Sc
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+ At
+ Hs

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Last updated: 15 Jul 2024