HitPredict

Interactor 1: AAPK1 (P54645)
5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
Gene: Prkaa1

Interactor 2: HNRPD (Q9JJ54)
Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1)
Gene: Hnrnpd

Species: Rattus norvegicus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	24625528
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0003682 - chromatin binding GO:0005829 - cytosol GO:0010628 - positive regulation of gene expression GO:0010629 - negative regulation of gene expression GO:0042752 - regulation of circadian rhythm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 559 Rn			1 353
+	Rn
		871320 AAPK1_RAT (1-559): 0: 586: 100.00		ROA3_RAT (72-306): 2.25e-72: 231: 36.36
+	Rn
		871344 AAPK1_RAT (1-559): 0: 586: 100.00		Q9Z0U8_RAT (64-303): 7.48e-55: 183: 57.50
+	Rn
		871338 AAPK1_RAT (1-559): 0: 586: 100.00		Q9QX80_RAT (22-353): 5.52e-53: 178: 45.78
+	Rn
		871332 AAPK1_RAT (1-559): 0: 586: 100.00		PABP1_RAT (87-270): 6.53e-41: 153: 17.02
+	Rn
		64994 AAPK1_RAT (1-559): 0: 586: 100.00		ROA2_RAT (96-275): 1.37e-38: 142: 41.40
+	Rn
		380432 AAPK1_RAT (1-559): 0: 586: 100.00		ROA1_RAT (64-175): 2.78e-19: 88.9: 27.50
+	Hs
		161966 MARK3_HUMAN (2-536): 1.6e-143: 434: 28.57		HNRDL_HUMAN (87-353): 4.7e-57: 192: 61.92