HitPredict

Interactor 1: AAPK2 (P54646)
5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31)
Gene: PRKAA2

Interactor 2: CACO2 (Q13137)
Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52)
Gene: CALCOCO2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.653

Property	Details
Experiments	32296183, 36736316, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0046872 - metal ion binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 552 Hs			1 446
+	Hs
		1025126 AAPK1_HUMAN (2-552): 0: 535: 74.86		CACO2_HUMAN (1-446): 3.19e-64: 215: 100.00
+	Hs
		871492 AAPK2_HUMAN (1-552): 0: 570: 100.00		CACO1_HUMAN (91-407): 9.18e-09: 59.7: 14.07
+	Rn
		871291 AAPK1_RAT (2-552): 0: 530: 74.68		MYH9_RAT (144-341): 2.12e-09: 62.1: 14.83
+	Rn
		102485 AAPK1_RAT (2-552): 0: 530: 74.68		G3V6P7_RAT (144-345): 3.6e-09: 61.4: 14.56
+	Rn
		871335 AAPK1_RAT (2-552): 0: 530: 74.68		MYH10_RAT (60-417): 3.37e-09: 61.3: 12.06
+	Hs
		1183078 MARK2_HUMAN (6-545): 9.52e-149: 448: 29.22		DLG5_HUMAN (77-439): 7.24e-18: 88.6: 10.03
+	Hs
		647929 MARK3_HUMAN (8-552): 5.72e-142: 429: 27.52		DLG5_HUMAN (77-439): 7.24e-18: 88.6: 10.03
+	Hs
		1051339 MARK2_HUMAN (6-545): 9.52e-149: 448: 29.22		DCTN1_HUMAN (104-339): 7.78e-10: 63.2: 10.83
+	Hs
		1268074 MARK4_HUMAN (7-536): 2.33e-142: 430: 28.63		MY18A_HUMAN (127-365): 3.21e-10: 64.8: 15.81
+	Hs
		725223 MARK4_HUMAN (7-536): 2.33e-142: 430: 28.63		MYH10_HUMAN (60-417): 3.37e-09: 61.3: 12.06
+	Hs
		724967 MARK4_HUMAN (7-536): 2.33e-142: 430: 28.63		MYH9_HUMAN (144-345): 7.94e-09: 60.2: 15.05
+	Hs
		728513 SIK2_HUMAN (1-400): 3.94e-134: 414: 37.69		MYH11_HUMAN (85-439): 1.1e-09: 62.8: 8.29
+	Hs
		725242 SIK2_HUMAN (1-400): 3.94e-134: 414: 37.69		MYH10_HUMAN (60-417): 3.37e-09: 61.3: 12.06
+	Hs
		725010 SIK2_HUMAN (1-400): 3.94e-134: 414: 37.69		MYH9_HUMAN (144-345): 7.94e-09: 60.2: 15.05