HitPredict

Interactor 1: AAPK2 (P54646)
5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31)
Gene: PRKAA2

Interactor 2: AAKB1 (Q9Y478)
5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb)
Gene: PRKAB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.971

The method score is based on:

Property Details
Experiments 31900314, 32707033, 36736316, 28514442, 32296183, 33961781, 20562859, unassigned1304
Identification Methods affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains AMPK1_CBM~AdenylateSensor, AMPKBI~AdenylateSensor, AMPK1_CBM~Pkinase, AMPKBI~Pkinase
Common GO terms GO:0004672 - protein kinase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 5 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 552
Hs

1 270
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+ Hs
+ Rn
+ Mm
+ Hs
+ At
+ Ce
+ At
+ Ce
+ At
+ At
+ Sp
+ At
+ At
+ Sc
+ Zm
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+ At
+ At
+ At

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Last updated: 15 Jul 2024