HitPredict

Interactor 1: RD23A (P54725)
UV excision repair protein RAD23 homolog A (HR23A) (hHR23A)
Gene: RAD23A

Interactor 2: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.670

Property	Details
Experiments	16189514, 19013454, 31515488
Identification Methods	two hybrid, affinity chromatography technology, pull down, two hybrid array, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043130 - ubiquitin binding GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 363 Hs			1 440
+	Rn
		139621 RD23B_RAT (3-363): 6.38e-109: 326: 52.05		SQSTM_RAT (1-440): 0: 746: 90.95
+	Hs
		1036982 UBQL2_HUMAN (2-312): 1.85e-45: 166: 16.08		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		475023 UBB_HUMAN (3-81): 4.96e-28: 111: 30.38		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		923979 RS27A_HUMAN (3-93): 2.9e-16: 77.1: 27.47		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		924341 RL40_HUMAN (3-129): 1.37e-38: 136: 22.84		MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19
+	Dr
		47648 Q3B7P7_DANRE (3-129): 1.54e-38: 135: 22.84		A0AR23_DANRE (106-247): 5.06e-22: 100: 23.61
+	Hs
		1056159 UBQL2_HUMAN (2-312): 1.85e-45: 166: 16.08		NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78
+	Dr
		47653 Q7SXA3_DANRE (3-93): 3.02e-16: 77.1: 27.47		A0AR23_DANRE (106-247): 5.06e-22: 100: 23.61