HitPredict

Interactor 1: RD23A (P54725)
UV excision repair protein RAD23 homolog A (HR23A) (hHR23A)
Gene: RAD23A

Interactor 2: HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Gene: HUWE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19013454
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UBA~UBA, HECT~ubiquitin, UBA~ubiquitin, UBM~ubiquitin, UBA~XPC-binding
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 363 Hs			1 4374
+	Hs
		803611 BAG6_HUMAN (2-307): 5.25e-38: 146: 15.22		HUWE1_HUMAN (1-4374): 0: 3240: 100.00
+	Hs
		924336 RL40_HUMAN (3-129): 1.37e-38: 136: 22.84		HUWE1_HUMAN (1-4374): 0: 3240: 100.00
+	Hs
		475080 UBB_HUMAN (3-81): 4.96e-28: 111: 30.38		HUWE1_HUMAN (1-4374): 0: 3240: 100.00
+	Mm
		924239 RS27A_MOUSE (3-93): 2.96e-16: 77.1: 27.47		HUWE1_MOUSE (1-4374): 0: 3203: 96.37
+	Hs
		125281 RD23A_HUMAN (1-363): 4.01e-119: 350: 100.00		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		872218 RD23A_HUMAN (1-363): 4.01e-119: 350: 100.00		SMUF1_HUMAN (3772-4371): 0: 620: 32.84
+	Hs
		125282 RD23B_HUMAN (3-363): 1.37e-106: 320: 54.03		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		125787 UBQL1_HUMAN (2-312): 9.5e-48: 171: 14.47		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		1336119 UBQL1_HUMAN (2-312): 9.5e-48: 171: 14.47		SMUF1_HUMAN (3772-4371): 0: 620: 32.84
+	Hs
		125739 UBQL4_HUMAN (3-312): 3.05e-45: 165: 15.57		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		1336106 UBQL2_HUMAN (2-312): 1.85e-45: 166: 16.08		SMUF1_HUMAN (3772-4371): 0: 620: 32.84
+	Hs
		475140 UBB_HUMAN (3-81): 4.96e-28: 111: 30.38		ITCH_HUMAN (3507-4372): 0: 672: 23.10
+	Hs
		125225 BAG6_HUMAN (2-307): 5.25e-38: 146: 15.22		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		924414 RL40_HUMAN (3-129): 1.37e-38: 136: 22.84		SMUF2_HUMAN (3771-4371): 0: 611: 33.44
+	Hs
		125112 UBB_HUMAN (3-81): 4.96e-28: 111: 30.38		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		475196 UBB_HUMAN (3-81): 4.96e-28: 111: 30.38		SMUF2_HUMAN (3771-4371): 0: 611: 33.44
+	Sp
		145418 RL402_SCHPO (3-129): 2.29e-37: 132: 21.26		PUB3_SCHPO (3746-4372): 4.19e-180: 577: 29.70
+	Hs
		474953 UBB_HUMAN (3-81): 4.96e-28: 111: 30.38		NEDD4_HUMAN (3104-4372): 2.46e-179: 594: 21.46
+	Dm
		89880 RL40_DROME (3-129): 2.8e-38: 134: 22.84		D5SHR3_DROME (3965-4373): 1.32e-179: 561: 37.14
+	Sc
		477647 RL40A_YEAST (3-129): 1.25e-32: 120: 20.47		TOM1_YEAST (3831-4374): 1.99e-157: 554: 43.77