HitPredict

Interactor 1: RD23B (P54727)
UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58)
Gene: RAD23B

Interactor 2: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.879

Property	Details
Experiments	10373495, 22645313, 29426014
Identification Methods	pull down, affinity chromatography technology, two hybrid, enzymatic study, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 409 Hs			1 875
+	Rn
		94339 RD23B_RAT (1-409): 1.14e-120: 358: 87.23		F1M7B8_RAT (7-875): 0: 1023: 95.63
+	Hs
		872147 RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72		UBE3A_HUMAN (1-875): 0: 1058: 100.00
+	Hs
		983269 UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72		UBE3A_HUMAN (1-875): 0: 1058: 100.00
+	Hs
		983264 UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68		UBE3A_HUMAN (1-875): 0: 1058: 100.00
+	Hs
		125282 RD23B_HUMAN (1-409): 1.31e-125: 370: 100.00		WWP2_HUMAN (291-873): 0: 589: 24.72
+	Hs
		125281 RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72		WWP2_HUMAN (291-873): 0: 589: 24.72
+	Hs
		872218 RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72		SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04
+	Hs
		125787 UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72		WWP2_HUMAN (291-873): 0: 589: 24.72
+	Hs
		1065056 UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72		HERC3_HUMAN (139-874): 0: 582: 26.85
+	Hs
		1065054 UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68		HERC3_HUMAN (139-874): 0: 582: 26.85
+	Hs
		125739 UBQL4_HUMAN (1-364): 2.75e-45: 166: 12.71		WWP2_HUMAN (291-873): 0: 589: 24.72
+	Hs
		1355829 UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72		HERC5_HUMAN (153-873): 1.77e-175: 536: 23.20
+	Hs
		1336119 UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72		SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04
+	Hs
		1218013 UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68		HERC6_HUMAN (151-872): 1.74e-172: 528: 24.09
+	Hs
		1336106 UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68		SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04
+	Mm
		476846 UBC_MOUSE (1-118): 1.78e-32: 131: 21.67		HERC4_MOUSE (157-875): 0: 568: 27.46
+	Mm
		477022 UBC_MOUSE (1-118): 1.78e-32: 131: 21.67		UBE3B_MOUSE (396-874): 8.89e-149: 467: 24.03
+	Hs
		872180 RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72		HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97
+	Mm
		476858 UBC_MOUSE (1-118): 1.78e-32: 131: 21.67		HUWE1_MOUSE (523-874): 7.59e-53: 203: 33.97
+	Mm
		476866 UBC_MOUSE (1-118): 1.78e-32: 131: 21.67		UBE3C_MOUSE (453-872): 3.25e-52: 200: 32.73