HitPredict

Interactor 1: RD23B (P54727)
UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58)
Gene: RAD23B

Interactor 2: PSMD6 (Q15008)
26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A)
Gene: PSMD6

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	32025036, 27114451, 16424905
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RPN7~ubiquitin
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 409 Hs			1 389
+	Rn
		1117340 RD23B_RAT (1-409): 1.14e-120: 358: 87.23		Q6PCT9_RAT (1-389): 2.3e-136: 396: 97.94
+	Hs
		872158 RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72		PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00
+	Dm
		1358524 Q9V3W9_DROME (1-408): 5.38e-89: 277: 36.75		PSMD6_DROME (1-389): 2.36e-125: 368: 70.18
+	Hs
		121715 RD23B_HUMAN (1-409): 1.31e-125: 370: 100.00		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Rn
		78168 RD23B_RAT (1-409): 1.14e-120: 358: 87.23		B5DEP6_RAT (3-387): 3.08e-77: 246: 11.03
+	Hs
		1062897 UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72		PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00
+	Hs
		1062891 UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68		PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00
+	Hs
		1062884 UBQL4_HUMAN (1-364): 2.75e-45: 166: 12.71		PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00
+	Hs
		121714 RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Dm
		1358537 Q9VWD9_DROME (1-353): 1.07e-44: 164: 11.08		PSMD6_DROME (1-389): 2.36e-125: 368: 70.18
+	Sc
		697117 RAD23_YEAST (1-407): 2.12e-72: 233: 28.41		RPN7_YEAST (11-389): 3.41e-86: 269: 35.47
+	Hs
		121871 UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Mm
		102344 UBC_MOUSE (1-118): 1.78e-32: 131: 21.67		G3UXW9_MOUSE (12-389): 2.02e-98: 304: 21.48
+	Hs
		121867 UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Sc
		697128 RAD23_YEAST (1-407): 2.12e-72: 233: 28.41		RPN6_YEAST (30-389): 1.53e-56: 192: 12.57
+	Hs
		888457 UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68		EIF3E_HUMAN (26-387): 7.71e-74: 238: 14.04
+	Hs
		121863 UBQL4_HUMAN (1-364): 2.75e-45: 166: 12.71		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Mm
		476740 UBC_MOUSE (1-118): 1.78e-32: 131: 21.67		CSN2_MOUSE (22-388): 5.37e-90: 280: 13.67
+	Dm
		1180727 Q9VWD9_DROME (1-353): 1.07e-44: 164: 11.08		PSD11_DROME (7-387): 4.3e-77: 246: 13.32
+	Mm
		476877 UBC_MOUSE (1-118): 1.78e-32: 131: 21.67		PSD11_MOUSE (3-387): 6.46e-77: 245: 11.03