HitPredict

Interactor 1: EPHA4 (P54764)
Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK)
Gene: EPHA4

Interactor 2: GRB10 (Q13322)
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Gene: GRB10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	unassigned1973
Identification Methods	two hybrid fragment pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 986 Hs			1 594
+	Hs
		872612 EPHB1_HUMAN (29-983): 0: 1179: 59.19		GRB10_HUMAN (1-594): 0: 712: 100.00
+	Hs
		872614 EPHB1_HUMAN (29-983): 0: 1179: 59.19		GRB7_HUMAN (107-594): 1.36e-174: 507: 55.60
+	Hs
		855777 EPHA4_HUMAN (1-986): 0: 1293: 100.00		VAV2_HUMAN (40-588): 1.7e-95: 313: 12.26
+	Hs
		412105 EPHA4_HUMAN (1-986): 0: 1293: 100.00		FYN_HUMAN (441-591): 5.64e-47: 174: 20.38
+	Hs
		522871 EPHA4_HUMAN (1-986): 0: 1293: 100.00		SRC_HUMAN (443-590): 9.55e-47: 174: 22.08
+	Hs
		433662 EPHA4_HUMAN (1-986): 0: 1293: 100.00		LYN_HUMAN (409-593): 7.45e-46: 171: 17.19
+	Mm
		763386 EPHA4_MOUSE (1-986): 0: 1289: 98.58		FYN_MOUSE (441-591): 5.64e-47: 174: 20.38
+	Hs
		872630 EPHA4_HUMAN (1-986): 0: 1293: 100.00		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		433772 EPHA7_HUMAN (5-986): 0: 1212: 62.37		LYN_HUMAN (409-593): 7.45e-46: 171: 17.19
+	Hs
		412104 EPHA5_HUMAN (2-986): 0: 1201: 63.67		FYN_HUMAN (441-591): 5.64e-47: 174: 20.38
+	Hs
		412036 EPHA3_HUMAN (26-986): 0: 1182: 63.01		FYN_HUMAN (441-591): 5.64e-47: 174: 20.38
+	Hs
		522802 EPHA3_HUMAN (26-986): 0: 1182: 63.01		SRC_HUMAN (443-590): 9.55e-47: 174: 22.08
+	Hs
		433602 EPHA3_HUMAN (26-986): 0: 1182: 63.01		LYN_HUMAN (409-593): 7.45e-46: 171: 17.19
+	Mm
		403425 EPHB2_MOUSE (30-984): 0: 1171: 58.51		SRC_MOUSE (443-590): 1.24e-46: 173: 22.08
+	Hs
		433265 EPHB2_HUMAN (30-983): 0: 1169: 58.47		YES_HUMAN (441-592): 9.17e-47: 174: 20.89
+	Hs
		924590 EPHA7_HUMAN (5-986): 0: 1212: 62.37		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		872422 EPHA5_HUMAN (2-986): 0: 1201: 63.67		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		665389 EPHA3_HUMAN (26-986): 0: 1182: 63.01		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		872610 EPHB1_HUMAN (29-983): 0: 1179: 59.19		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Mm
		872621 EPHB2_MOUSE (30-984): 0: 1171: 58.51		GRB2_MOUSE (489-575): 3.64e-20: 91.4: 29.89