HitPredict

Interactor 1: EPHA4 (P54764)
Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK)
Gene: EPHA4

Interactor 2: EFNB3 (Q15768)
Ephrin-B3 (EPH-related receptor transmembrane ligand ELK-L3) (EPH-related receptor tyrosine kinase ligand 8) (LERK-8)
Gene: EFNB3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 1.00 0.902

The method score is based on:

Property Details
Experiments 9484836, 28514442, 33961781, 23812375
Identification Methods pull down, affinity chromatography technology, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ephrin~Ephrin_lbd
Common GO terms GO:0005005 - transmembrane-ephrin receptor activity
GO:0005886 - plasma membrane
GO:0007411 - axon guidance
GO:0007628 - adult walking behavior
GO:0042734 - presynaptic membrane
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 986
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024