HitPredict

Interactor 1: SNAA (P54920)
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha)
Gene: NAPA

Interactor 2: VAMP8 (Q9BV40)
Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB)
Gene: VAMP8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.866

Property	Details
Experiments	9614193, 33961781, 35271311
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	SNAP~Synaptobrevin
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0019905 - syntaxin binding GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 295 Hs			1 100
+	Hs
		850546 SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00		VAMP7_HUMAN (1-100): 1.25e-26: 99.2: 38.00
+	Hs
		261646 SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00		VAMP4_HUMAN (7-80): 3.4e-25: 93.4: 29.73
+	Hs
		261720 SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25		VAMP4_HUMAN (7-80): 3.4e-25: 93.4: 29.73
+	Dm
		1095560 SNAP_DROME (5-295): 7.84e-105: 308: 61.51		Q7JYX5_DROME (1-100): 8.7e-32: 112: 32.00
+	Hs
		873545 SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		873528 SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00		VAMP2_HUMAN (6-82): 2.47e-23: 88: 35.07
+	Mm
		659546 SNAB_MOUSE (1-292): 6.03e-113: 329: 84.25		VAMP2_MOUSE (6-82): 2.47e-23: 88: 35.07
+	Dm
		577215 SNAP_DROME (5-295): 7.84e-105: 308: 61.51		SYB_DROME (5-95): 3.25e-30: 106: 27.47
+	Zm
		31296 A0A1D6PZ82_MAIZE (5-272): 3.97e-89: 271: 36.80		A0A1D6KH00_MAIZE (6-98): 2.6e-36: 131: 24.73
+	Sc
		696608 SEC17_YEAST (8-294): 4.63e-88: 266: 34.48		NYV1_YEAST (3-99): 2.82e-22: 88.4: 24.75
+	Sc
		678143 SEC17_YEAST (8-294): 4.63e-88: 266: 34.48		SNC1_YEAST (2-79): 5.22e-23: 86.9: 26.92
+	Hs
		850592 SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40		VAMP7_HUMAN (1-100): 1.25e-26: 99.2: 38.00
+	Hs
		261710 SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40		VAMP4_HUMAN (7-80): 3.4e-25: 93.4: 29.73
+	Hs
		1079416 SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		1306201 SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40		VAMP8_HUMAN (1-100): 2.94e-24: 89.6: 100.00
+	Hs
		926249 SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40		VAMP2_HUMAN (6-82): 2.47e-23: 88: 35.07
+	Dm
		1178116 Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49		Q7JYX5_DROME (1-100): 8.7e-32: 112: 32.00
+	Dm
		577238 Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49		SYB_DROME (5-95): 3.25e-30: 106: 27.47
+	Dm
		1178122 Q9VH25_DROME (18-265): 1.8e-53: 177: 17.53		Q7JYX5_DROME (1-100): 8.7e-32: 112: 32.00