HitPredict

Interactor 1: PSMD4 (P55035)
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (54 kDa subunit of mu particle) (Multiubiquitin chain-binding protein) (p54)
Gene: Rpn10

Interactor 2: Q9VXF9 (Q9VXF9)
AT13091p (GM04721p) (Rings lost, isoform A (EC 3.4.23.-)) (Rings lost, isoform B)
Gene: rngo

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	21444692
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UIM~ubiquitin, VWA_2~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 396 Dm			1 458
+	Hs
		874144 PSMD4_HUMAN (1-384): 1.25e-174: 493: 53.51		DDI1_HUMAN (1-392): 3.38e-148: 429: 47.61
+	Hs
		874117 PSMD4_HUMAN (1-384): 1.25e-174: 493: 53.51		DDI2_HUMAN (1-394): 1.04e-139: 408: 47.19
+	Hs
		874198 PSMD4_HUMAN (1-384): 1.25e-174: 493: 53.51		UBQL1_HUMAN (1-230): 8.47e-48: 175: 18.63
+	Hs
		874195 PSMD4_HUMAN (1-384): 1.25e-174: 493: 53.51		UBQL2_HUMAN (1-230): 3.37e-45: 168: 16.73
+	Sc
		756936 RPN10_YEAST (1-225): 2.03e-99: 298: 42.37		DDI1_YEAST (1-447): 1.95e-119: 357: 28.79
+	Dm
		874046 PSMD4_DROME (1-396): 1.39e-168: 478: 100.00		Q9VWD9_DROME (1-230): 1.27e-45: 168: 18.85
+	Xl
		1118797 Q4V845_XENLA (1-384): 1.43e-172: 488: 53.25		Q9PVN8_XENLA (1-221): 1.65e-36: 143: 16.49
+	Hs
		874185 PSMD4_HUMAN (1-384): 1.25e-174: 493: 53.51		UBQL4_HUMAN (1-221): 7.9e-35: 138: 13.19
+	Hs
		872242 PSMD4_HUMAN (1-384): 1.25e-174: 493: 53.51		RD23B_HUMAN (1-209): 6.36e-32: 128: 13.81
+	Rn
		1117345 Q9ESH1_RAT (1-384): 2.79e-175: 495: 53.51		RD23B_RAT (1-209): 1.77e-28: 118: 14.64
+	Hs
		874068 PSMD4_HUMAN (1-384): 1.25e-174: 493: 53.51		RS27A_HUMAN (1-89): 9.34e-27: 107: 25.84
+	Hs
		803454 PSMD4_HUMAN (1-384): 1.25e-174: 493: 53.51		BAG6_HUMAN (1-112): 1.32e-19: 94.1: 22.32
+	Dm
		547908 PSMD4_DROME (1-396): 1.39e-168: 478: 100.00		RS27A_DROME (1-89): 4.08e-27: 107: 26.97
+	At
		874024 PSMD4_ARATH (1-396): 6.77e-141: 408: 40.44		DSK2B_ARATH (3-244): 2.4e-45: 167: 17.27
+	Sc
		756974 RPN10_YEAST (1-225): 2.03e-99: 298: 42.37		DSK2_YEAST (1-199): 6.47e-30: 121: 16.90