HitPredict

Interactor 1: PSMD4 (P55036)
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein)
Gene: PSMD4

Interactor 2: PSMD6 (Q15008)
26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A)
Gene: PSMD6

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	17353931, 35271311, 33961781, 27114451, 16990800
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0022624 - proteasome accessory complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 389
+	Hs
		121716 PSMD4_HUMAN (1-364): 0: 530: 100.00		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Hs
		121793 Q5VWC4_HUMAN (1-364): 0: 525: 99.18		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Sc
		757030 RPN10_YEAST (1-224): 1.27e-98: 295: 49.15		RPN7_YEAST (11-389): 3.41e-86: 269: 35.47
+	Sc
		757050 RPN10_YEAST (1-224): 1.27e-98: 295: 49.15		RPN6_YEAST (30-389): 1.53e-56: 192: 12.57