HitPredict

Interactor 1: PSMD4 (P55036)
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein)
Gene: PSMD4

Interactor 2: DDI1 (Q8WTU0)
Protein DDI1 homolog 1 (EC 3.4.23.-)
Gene: DDI1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	27114451
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UIM~ubiquitin, VWA_2~ubiquitin
Common GO terms	-
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 396
+	Hs
		874117 PSMD4_HUMAN (1-364): 0: 530: 100.00		DDI2_HUMAN (1-392): 2.76e-155: 445: 70.93
+	Dm
		874047 PSMD4_DROME (1-359): 6.74e-149: 428: 57.40		Q9VXF9_DROME (5-395): 3.91e-131: 386: 47.58
+	Hs
		874198 PSMD4_HUMAN (1-364): 0: 530: 100.00		UBQL1_HUMAN (5-249): 3.83e-47: 171: 14.74
+	Hs
		874195 PSMD4_HUMAN (1-364): 0: 530: 100.00		UBQL2_HUMAN (5-249): 4.55e-46: 168: 14.74
+	Hs
		874185 PSMD4_HUMAN (1-364): 0: 530: 100.00		UBQL4_HUMAN (8-249): 3.58e-43: 160: 14.24
+	Xl
		1118797 Q4V845_XENLA (1-364): 0: 519: 91.48		Q9PVN8_XENLA (31-249): 2.71e-40: 152: 14.86
+	Xl
		1118798 Q4V845_XENLA (1-364): 0: 519: 91.48		BAG6A_XENLA (4-247): 1.18e-28: 120: 14.92
+	Hs
		803454 PSMD4_HUMAN (1-364): 0: 530: 100.00		BAG6_HUMAN (4-168): 1.28e-24: 108: 15.25
+	Hs
		874068 PSMD4_HUMAN (1-364): 0: 530: 100.00		RS27A_HUMAN (5-93): 5.56e-24: 98.8: 17.98
+	At
		874024 PSMD4_ARATH (1-377): 4.15e-138: 400: 41.32		DSK2B_ARATH (4-249): 1.6e-54: 190: 19.69
+	Dm
		874046 PSMD4_DROME (1-359): 6.74e-149: 428: 57.40		Q9VWD9_DROME (5-249): 3.39e-41: 154: 13.55
+	Sc
		756936 RPN10_YEAST (1-224): 1.27e-98: 295: 49.15		DDI1_YEAST (14-369): 1.01e-91: 284: 29.41
+	Dm
		874036 PSMD4_DROME (1-359): 6.74e-149: 428: 57.40		Q9VCD5_DROME (5-218): 1.23e-30: 120: 18.92
+	Sc
		756974 RPN10_YEAST (1-224): 1.27e-98: 295: 49.15		DSK2_YEAST (14-202): 5.04e-25: 106: 17.84