HitPredict

Interactor 1: PSMD4 (P55036)
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein)
Gene: PSMD4

Interactor 2: UBQL4 (Q9NRR5)
Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75)
Gene: UBQLN4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.909

Property	Details
Experiments	29666234, 30664872, 15280365, 18079109, 24256120
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	UIM~ubiquitin, VWA_2~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031593 - polyubiquitin modification-dependent protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 601
+	Hs
		874198 PSMD4_HUMAN (1-364): 0: 530: 100.00		UBQL1_HUMAN (11-601): 1.16e-127: 389: 59.16
+	Xl
		1118797 Q4V845_XENLA (1-364): 0: 519: 91.48		Q9PVN8_XENLA (2-601): 1.1e-125: 383: 70.00
+	Hs
		874195 PSMD4_HUMAN (1-364): 0: 530: 100.00		UBQL2_HUMAN (9-601): 6.99e-118: 365: 51.59
+	Dm
		874046 PSMD4_DROME (1-359): 6.74e-149: 428: 57.40		Q9VWD9_DROME (10-594): 3.44e-109: 340: 44.26
+	Xl
		1118798 Q4V845_XENLA (1-364): 0: 519: 91.48		BAG6A_XENLA (13-547): 2.1e-69: 245: 18.02
+	Hs
		803454 PSMD4_HUMAN (1-364): 0: 530: 100.00		BAG6_HUMAN (2-547): 7.28e-64: 229: 13.41
+	Hs
		872125 PSMD4_HUMAN (1-364): 0: 530: 100.00		RD23A_HUMAN (13-318): 1.95e-47: 172: 16.37
+	Rn
		1117345 Q9ESH1_RAT (1-364): 0: 529: 98.90		RD23B_RAT (13-275): 1.12e-39: 152: 17.40
+	At
		874024 PSMD4_ARATH (1-377): 4.15e-138: 400: 41.32		DSK2B_ARATH (19-598): 1.53e-84: 276: 30.22
+	Hs
		872242 PSMD4_HUMAN (1-364): 0: 530: 100.00		RD23B_HUMAN (13-275): 2e-37: 145: 18.29
+	Hs
		874069 PSMD4_HUMAN (1-364): 0: 530: 100.00		RL40_HUMAN (13-103): 6.24e-34: 127: 28.26
+	Dm
		874035 PSMD4_DROME (1-359): 6.74e-149: 428: 57.40		Q9V3W9_DROME (13-357): 7.4e-47: 171: 13.19
+	Hs
		874068 PSMD4_HUMAN (1-364): 0: 530: 100.00		RS27A_HUMAN (13-99): 1.11e-12: 68.1: 29.55
+	Zm
		22892 A0A1D6KBS7_MAIZE (1-338): 5.73e-134: 388: 37.57		A0A1D6I428_MAIZE (13-311): 3.08e-51: 184: 15.01
+	At
		874016 PSMD4_ARATH (1-377): 4.15e-138: 400: 41.32		RD23D_ARATH (13-307): 5.4e-47: 171: 13.97
+	At
		874018 PSMD4_ARATH (1-377): 4.15e-138: 400: 41.32		RD23A_ARATH (13-310): 9.52e-45: 164: 14.20
+	At
		874019 PSMD4_ARATH (1-377): 4.15e-138: 400: 41.32		RD23B_ARATH (13-310): 1.76e-42: 158: 14.66
+	At
		874017 PSMD4_ARATH (1-377): 4.15e-138: 400: 41.32		RD23C_ARATH (13-321): 2.25e-41: 156: 13.24
+	At
		874015 PSMD4_ARATH (1-377): 4.15e-138: 400: 41.32		UBQ3_ARATH (9-88): 1.35e-32: 129: 30.86
+	Dm
		547908 PSMD4_DROME (1-359): 6.74e-149: 428: 57.40		RS27A_DROME (13-99): 1.5e-12: 67.7: 30.68