HitPredict

Interactor 1: PSMD4 (P55036)
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein)
Gene: PSMD4

Interactor 2: UBQL2 (Q9UHD9)
Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)
Gene: UBQLN2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.939

Property	Details
Experiments	30664872, 30442662, 33277362, 27114451, 36827983, 20059542
Identification Methods	x-ray crystallography, affinity chromatography technology, pull down
Interaction Type	association, physical association, direct interaction

Property	Details
Interacting Pfam domains	UIM~ubiquitin, VWA_2~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0031593 - polyubiquitin modification-dependent protein binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 624
+	Hs
		874198 PSMD4_HUMAN (1-364): 0: 530: 100.00		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		874185 PSMD4_HUMAN (1-364): 0: 530: 100.00		UBQL4_HUMAN (22-624): 2.17e-124: 382: 54.55
+	Xl
		1118797 Q4V845_XENLA (1-364): 0: 519: 91.48		Q9PVN8_XENLA (14-624): 7.22e-124: 380: 52.43
+	Dm
		874046 PSMD4_DROME (1-359): 6.74e-149: 428: 57.40		Q9VWD9_DROME (26-617): 4.15e-130: 395: 44.35
+	Xl
		1118798 Q4V845_XENLA (1-364): 0: 519: 91.48		BAG6A_XENLA (28-578): 4.07e-61: 222: 15.47
+	Hs
		803454 PSMD4_HUMAN (1-364): 0: 530: 100.00		BAG6_HUMAN (21-580): 4.44e-53: 198: 15.23
+	Hs
		874144 PSMD4_HUMAN (1-364): 0: 530: 100.00		DDI1_HUMAN (43-314): 2.92e-54: 191: 15.60
+	Hs
		874117 PSMD4_HUMAN (1-364): 0: 530: 100.00		DDI2_HUMAN (43-314): 6.26e-52: 185: 14.59
+	At
		874024 PSMD4_ARATH (1-377): 4.15e-138: 400: 41.32		DSK2B_ARATH (15-544): 6.1e-93: 298: 28.13
+	Hs
		874069 PSMD4_HUMAN (1-364): 0: 530: 100.00		RL40_HUMAN (33-112): 7.49e-34: 127: 30.86
+	Hs
		874068 PSMD4_HUMAN (1-364): 0: 530: 100.00		RS27A_HUMAN (33-119): 4.49e-24: 100: 27.27
+	Dm
		874047 PSMD4_DROME (1-359): 6.74e-149: 428: 57.40		Q9VXF9_DROME (33-313): 1.35e-51: 186: 15.86
+	Dm
		874036 PSMD4_DROME (1-359): 6.74e-149: 428: 57.40		Q9VCD5_DROME (33-258): 3.37e-32: 127: 15.58
+	Dm
		547908 PSMD4_DROME (1-359): 6.74e-149: 428: 57.40		RS27A_DROME (33-103): 6.99e-13: 68.4: 33.33
+	Sc
		756974 RPN10_YEAST (1-224): 1.27e-98: 295: 49.15		DSK2_YEAST (32-239): 1.13e-31: 128: 31.19