HitPredict

Interactor 1: PSMD4 (P55036)
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein)
Gene: PSMD4

Interactor 2: UBQL1 (Q9UMX0)
Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)
Gene: UBQLN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.976

Property	Details
Experiments	28075048, 30664872, 31175912, 27114451, 36827983, 16862145, 15147878, 11827521, 20059542, 17082820
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	UIM~ubiquitin, VWA_2~ubiquitin
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031593 - polyubiquitin modification-dependent protein binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 589
+	Hs
		874195 PSMD4_HUMAN (1-364): 0: 530: 100.00		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		874185 PSMD4_HUMAN (1-364): 0: 530: 100.00		UBQL4_HUMAN (28-589): 1.35e-135: 409: 57.64
+	Xl
		1118797 Q4V845_XENLA (1-364): 0: 519: 91.48		Q9PVN8_XENLA (16-589): 3.64e-137: 413: 57.71
+	Dm
		874046 PSMD4_DROME (1-359): 6.74e-149: 428: 57.40		Q9VWD9_DROME (30-582): 3.32e-135: 407: 47.39
+	Xl
		1118798 Q4V845_XENLA (1-364): 0: 519: 91.48		BAG6A_XENLA (31-536): 8.79e-64: 229: 15.26
+	At
		874024 PSMD4_ARATH (1-377): 4.15e-138: 400: 41.32		DSK2B_ARATH (19-586): 1.62e-110: 343: 32.59
+	Hs
		874144 PSMD4_HUMAN (1-364): 0: 530: 100.00		DDI1_HUMAN (47-318): 6.39e-53: 187: 15.60
+	Hs
		874117 PSMD4_HUMAN (1-364): 0: 530: 100.00		DDI2_HUMAN (47-318): 2.03e-49: 178: 13.52
+	Hs
		803454 PSMD4_HUMAN (1-364): 0: 530: 100.00		BAG6_HUMAN (25-536): 2.14e-33: 138: 14.66
+	Hs
		874069 PSMD4_HUMAN (1-364): 0: 530: 100.00		RL40_HUMAN (37-126): 1.88e-34: 128: 30.77
+	Dm
		874047 PSMD4_DROME (1-359): 6.74e-149: 428: 57.40		Q9VXF9_DROME (37-317): 4.08e-51: 184: 17.93
+	Hs
		874068 PSMD4_HUMAN (1-364): 0: 530: 100.00		RS27A_HUMAN (37-123): 1.1e-12: 68: 30.68
+	Dm
		874035 PSMD4_DROME (1-359): 6.74e-149: 428: 57.40		Q9V3W9_DROME (37-394): 1.42e-40: 154: 13.95
+	Dm
		547908 PSMD4_DROME (1-359): 6.74e-149: 428: 57.40		RS27A_DROME (37-107): 1.11e-12: 68: 36.11
+	Sp
		293402 RPN10_SCHPO (1-245): 5.11e-104: 308: 45.75		RL402_SCHPO (37-126): 3.84e-31: 119: 29.67
+	Sc
		697082 RPN10_YEAST (1-224): 1.27e-98: 295: 49.15		RAD23_YEAST (45-419): 1.17e-31: 128: 17.73
+	Sc
		756974 RPN10_YEAST (1-224): 1.27e-98: 295: 49.15		DSK2_YEAST (36-243): 8.16e-32: 128: 30.73