HitPredict

Interactor 1: XPO2 (P55060)
Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)
Gene: CSE1L

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	31478661, 31871319
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CAS_CSE1~Ras, Cse1~Ras, IBN_N~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 971 Hs			1 191
+	Hs
		874588 XPO2_HUMAN (1-971): 0: 784: 100.00		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		874486 XPO2_HUMAN (1-971): 0: 784: 100.00		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		874477 XPO2_HUMAN (1-971): 0: 784: 100.00		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		178144 IPO8_HUMAN (7-962): 1.26e-161: 503: 18.13		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		312238 IPO7_HUMAN (7-880): 9.51e-158: 493: 19.02		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		925496 TNPO1_HUMAN (2-861): 1.05e-127: 410: 13.35		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		894563 IPO11_HUMAN (1-966): 7.87e-116: 380: 15.29		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		951442 IPO11_HUMAN (1-966): 7.87e-116: 380: 15.29		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		901027 IPO11_HUMAN (1-966): 7.87e-116: 380: 15.29		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		894326 IPO9_HUMAN (8-923): 1.04e-112: 373: 14.79		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		951243 IPO9_HUMAN (8-923): 1.04e-112: 373: 14.79		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		900811 IPO9_HUMAN (8-923): 1.04e-112: 373: 14.79		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		127230 IPO5_HUMAN (90-886): 1.85e-18: 93.4: 11.41		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		127302 IPO5_HUMAN (90-886): 1.85e-18: 93.4: 11.41		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82