HitPredict

Interactor 1: XPO2 (P55060)
Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)
Gene: CSE1L

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	31980649, 31871319, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CAS_CSE1~Ras, Cse1~Ras, IBN_N~Ras
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 971 Hs			1 192
+	Hs
		874588 XPO2_HUMAN (1-971): 0: 784: 100.00		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		874474 XPO2_HUMAN (1-971): 0: 784: 100.00		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		874477 XPO2_HUMAN (1-971): 0: 784: 100.00		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		178144 IPO8_HUMAN (7-962): 1.26e-161: 503: 18.13		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		312238 IPO7_HUMAN (7-880): 9.51e-158: 493: 19.02		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		925496 TNPO1_HUMAN (2-861): 1.05e-127: 410: 13.35		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		951442 IPO11_HUMAN (1-966): 7.87e-116: 380: 15.29		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		894563 IPO11_HUMAN (1-966): 7.87e-116: 380: 15.29		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		901027 IPO11_HUMAN (1-966): 7.87e-116: 380: 15.29		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		951243 IPO9_HUMAN (8-923): 1.04e-112: 373: 14.79		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		894326 IPO9_HUMAN (8-923): 1.04e-112: 373: 14.79		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		900811 IPO9_HUMAN (8-923): 1.04e-112: 373: 14.79		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		127230 IPO5_HUMAN (90-886): 1.85e-18: 93.4: 11.41		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31