HitPredict

Interactor 1: XPO2 (P55060)
Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)
Gene: CSE1L

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.657

Property	Details
Experiments	31046837, 21983832, unassigned1853
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006606 - protein import into nucleus GO:0031267 - small GTPase binding GO:0070062 - extracellular exosome
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 971 Hs			1 2527
+	Hs
		178183 IPO8_HUMAN (7-962): 1.26e-161: 503: 18.13		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		312289 IPO7_HUMAN (7-880): 9.51e-158: 493: 19.02		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130405 TNPO1_HUMAN (2-861): 1.05e-127: 410: 13.35		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130701 IPO11_HUMAN (1-966): 7.87e-116: 380: 15.29		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130463 IPO9_HUMAN (8-923): 1.04e-112: 373: 14.79		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		127289 IPO5_HUMAN (90-886): 1.85e-18: 93.4: 11.41		LRRK2_HUMAN (1-2527): 0: 3008: 99.72