Interactor 1: TERA (P55072)
Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)
Gene: VCP

Interactor 2: NPL4 (Q8TAT6)
Nuclear protein localization protein 4 homolog (Protein NPL4)
Gene: NPLOC4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.991

The method score is based on:

Property Details
Experiments 26389662, 28320958, 30335548, 31623962, 18586029, 35389758, 18775313, 26549226, 27226613, 27913212, 27762274, 29599191, 29540532, 28443643, 30344098, 33961781, 34262183, 34739333, 35271311, 17872946 and 7 others

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Identification Methods affinity chromatography technology, pull down, two hybrid, proximity labelling technology, x-ray crystallography, validated two hybrid, anti tag coimmunoprecipitation, two hybrid array, two hybrid pooling approach, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains AAA~NPL4, AAA~zf-NPL4, CDC48_2~UN_NPL4, CDC48_N~UN_NPL4
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
and 5 others

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Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 806
Hs

1 608
+ Rn
+ Mm
+ Xl
+ Dm
+ Sc
+ Sp

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024