HitPredict

Interactor 1: TERA (P55072)
Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)
Gene: VCP

Interactor 2: UBXN4 (Q92575)
UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2)
Gene: UBXN4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	19822669, 25078495, 29540532, 29997244, 35271311, 37071682, 26389662, 18775313, 16968747
Identification Methods	affinity chromatography technology, two hybrid, proximity labelling technology, fluorescent resonance energy transfer, cross-linking study, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CDC48_2~UBX, CDC48_N~UBX
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0036503 - ERAD pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 806 Hs			1 508
+	Ce
		712421 TERA1_CAEEL (3-806): 0: 702: 76.67		UBXN4_CAEEL (1-508): 2.98e-111: 339: 24.47
+	Ce
		712422 TERA2_CAEEL (2-784): 0: 701: 78.93		UBXN4_CAEEL (1-508): 2.98e-111: 339: 24.47
+	Hs
		299344 TERA_HUMAN (1-806): 0: 749: 100.00		UBXN7_HUMAN (2-397): 7.46e-87: 277: 15.33
+	Sc
		636608 CDC48_YEAST (2-806): 0: 720: 67.75		UBX7_YEAST (172-506): 3.04e-63: 214: 20.49
+	Hs
		875290 TERA_HUMAN (1-806): 0: 749: 100.00		ASPC1_HUMAN (89-457): 9.25e-51: 183: 15.82
+	Hs
		875432 TERA_HUMAN (1-806): 0: 749: 100.00		FAF1_HUMAN (171-397): 3.41e-47: 175: 19.38
+	Mm
		872336 TERA_MOUSE (1-806): 0: 749: 100.00		FAF1_MOUSE (171-397): 9.57e-47: 174: 19.82
+	Hs
		875209 TERA_HUMAN (1-806): 0: 749: 100.00		FAF2_HUMAN (89-394): 5.4e-45: 165: 11.18
+	Mm
		967687 TERA_MOUSE (1-806): 0: 749: 100.00		UBXN1_MOUSE (85-396): 5.82e-46: 164: 22.96
+	Hs
		874846 TERA_HUMAN (1-806): 0: 749: 100.00		UBXN1_HUMAN (85-396): 4.2e-44: 159: 22.64
+	At
		67566 CD48A_ARATH (3-806): 0: 718: 76.40		A8MRM0_ARATH (2-212): 7.17e-50: 179: 14.73
+	At
		870959 CD48A_ARATH (3-806): 0: 718: 76.40		PUX7_ARATH (2-212): 1.49e-49: 178: 14.73
+	Hs
		116676 TERA_HUMAN (1-806): 0: 749: 100.00		UBXN8_HUMAN (203-398): 1.28e-35: 135: 15.82
+	Dm
		1180101 TERA_DROME (5-806): 0: 734: 82.96		Q7K4I5_DROME (2-158): 5.23e-38: 147: 18.35
+	Sc
		636664 CDC48_YEAST (2-806): 0: 720: 67.75		UBX6_YEAST (266-461): 2.24e-43: 160: 21.11
+	Ce
		873005 TERA1_CAEEL (3-806): 0: 702: 76.67		UBXN1_CAEEL (85-393): 9.21e-49: 171: 21.32
+	Ce
		873015 TERA2_CAEEL (2-784): 0: 701: 78.93		UBXN1_CAEEL (85-393): 9.21e-49: 171: 21.32
+	Rn
		472980 TERA_RAT (1-806): 0: 751: 99.88		UBX2B_RAT (233-395): 6.19e-24: 104: 19.54
+	Hs
		874941 TERA_HUMAN (1-806): 0: 749: 100.00		UBX2B_HUMAN (233-395): 2.62e-22: 99.7: 18.97
+	At
		870957 CD48A_ARATH (3-806): 0: 718: 76.40		PUX5_ARATH (90-391): 1.12e-20: 96.2: 12.87