HitPredict

Interactor 1: TERA (P55072)
Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)
Gene: VCP

Interactor 2: FAF2 (Q96CS3)
FAS-associated factor 2 (UBX domain-containing protein 3B) (UBX domain-containing protein 8)
Gene: FAF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.984

The method score is based on:

Property Details
Experiments 25078495, 29599191, 29997244, 34739333, 35271311, 36300783, 18775313, 22119785, 22466964, 26389662, 18835813, 36746962, 18711132, 22350894, 23665563
Identification Methods two hybrid, affinity chromatography technology, fluorescent resonance energy transfer, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, luminescence based mammalian interactome mapping
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains CDC48_2~UBX, CDC48_N~UBX
Common GO terms GO:0005576 - extracellular region
GO:0005783 - endoplasmic reticulum
GO:0005811 - lipid droplet
GO:0030970 - retrograde protein transport, ER to cytosol
GO:0031625 - ubiquitin protein ligase binding
and 5 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 806
Hs

1 445
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+ Dm
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+ Ce
+ Ce
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+ Ce
+ Ce
+ Ce

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Last updated: 15 Jul 2024