HitPredict

Interactor 1: KBTBD (C9JR72)
Kelch repeat and BTB domain-containing protein 13
Gene: KBTBD13

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	22542517, 30190310
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BTB~Cullin
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 458 Hs			1 768
+	Hs
		296838 KBTBB_HUMAN (6-449): 8.13e-89: 284: 22.31		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042722 KLHL9_HUMAN (3-458): 2.38e-88: 283: 16.64		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042727 KLH13_HUMAN (3-458): 6.46e-88: 283: 16.29		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1041715 KLH22_HUMAN (58-444): 7.61e-87: 279: 21.04		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042725 KLH42_HUMAN (6-430): 4.06e-87: 276: 23.98		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042768 KLHL3_HUMAN (51-442): 2.12e-72: 240: 17.89		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042881 KLH20_HUMAN (40-442): 3.77e-72: 240: 16.99		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		307170 KLHL2_HUMAN (46-443): 3.47e-70: 235: 17.15		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		299515 KLH18_HUMAN (34-440): 5.58e-70: 234: 16.05		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042720 KLHL8_HUMAN (46-439): 2.37e-68: 230: 16.59		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Mm
		1225041 KLHL2_MOUSE (46-443): 2.6e-69: 232: 16.91		CUL3_MOUSE (1-768): 0: 949: 99.48
+	Rn
		78189 KLH17_RAT (20-456): 7.71e-68: 230: 17.88		CUL3_RAT (1-768): 0: 951: 99.61
+	Hs
		1041852 KLH17_HUMAN (20-456): 3.85e-67: 228: 18.32		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Dm
		1213843 Q9VGE5_DROME (17-442): 1.25e-70: 235: 14.48		Q8IP45_DROME (17-768): 0: 868: 69.08
+	Hs
		1043271 KLHL9_HUMAN (3-458): 2.38e-88: 283: 16.64		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1043281 KLHL3_HUMAN (51-442): 2.12e-72: 240: 17.89		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1041237 KLH13_HUMAN (3-458): 6.46e-88: 283: 16.29		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Rn
		70072 KLH17_RAT (20-456): 7.71e-68: 230: 17.88		B1WBY1_RAT (17-768): 0: 709: 30.53
+	Hs
		1274070 KLH42_HUMAN (6-430): 4.06e-87: 276: 23.98		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		299529 KLH18_HUMAN (34-440): 5.58e-70: 234: 16.05		CUL5_HUMAN (25-768): 0: 597: 23.77