HitPredict

Interactor 1: C9JXZ5 (C9JXZ5)
Vesicle-associated membrane protein 8 (Endobrevin)
Gene: VAMP8

Interactor 2: STX8 (Q9UNK0)
Syntaxin-8
Gene: STX8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin
Common GO terms	GO:0005484 - SNAP receptor activity GO:0005886 - plasma membrane GO:0019905 - syntaxin binding GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 74 Hs			1 236
+	Dm
		1178135 Q7JYX5_DROME (1-74): 9.14e-25: 93: 36.49		Q9VV76_DROME (4-223): 7.2e-43: 146: 24.32
+	Rn
		1144363 VAMP1_RAT (1-59): 3.51e-21: 81.5: 33.90		STX6_RAT (3-222): 3.2e-46: 155: 17.65
+	Dm
		577257 SYB_DROME (1-69): 2.94e-24: 89.9: 30.44		Q9VV76_DROME (4-223): 7.2e-43: 146: 24.32
+	Hs
		850607 VAMP7_HUMAN (1-74): 1.37e-19: 79.9: 39.19		STX8_HUMAN (1-218): 7.54e-47: 156: 100.00
+	At
		1351793 VA721_ARATH (1-73): 6.59e-24: 91.1: 38.36		SNP33_ARATH (11-210): 1.79e-38: 137: 15.69
+	Hs
		212772 VAMP7_HUMAN (1-74): 1.37e-19: 79.9: 39.19		STX6_HUMAN (3-221): 2.26e-43: 148: 17.30
+	At
		812701 VA722_ARATH (1-73): 4.73e-23: 88.8: 36.99		SNP33_ARATH (11-210): 1.79e-38: 137: 15.69
+	Hs
		212689 VAMP4_HUMAN (1-54): 4.65e-19: 76.5: 29.63		STX6_HUMAN (3-221): 2.26e-43: 148: 17.30
+	Sc
		704535 SNC2_YEAST (1-55): 1.24e-20: 79.9: 29.09		TLG1_YEAST (2-220): 3.95e-32: 118: 15.07
+	Sc
		975941 NYV1_YEAST (1-69): 2.67e-18: 76.8: 26.09		TLG1_YEAST (2-220): 3.95e-32: 118: 15.07
+	Hs
		320265 VAMP1_HUMAN (2-59): 1.15e-20: 79.9: 32.76		SNP29_HUMAN (10-207): 2.95e-28: 109: 20.50
+	Hs
		320281 VAMP7_HUMAN (1-74): 1.37e-19: 79.9: 39.19		SNP29_HUMAN (10-207): 2.95e-28: 109: 20.50
+	Sc
		701249 SNC2_YEAST (1-55): 1.24e-20: 79.9: 29.09		VAM7_YEAST (46-211): 1.29e-25: 103: 21.56
+	Sc
		611769 SNC2_YEAST (1-55): 1.24e-20: 79.9: 29.09		BET1_YEAST (93-235): 4.89e-27: 102: 18.06
+	Dm
		577224 SYB_DROME (1-69): 2.94e-24: 89.9: 30.44		Q7JRF1_DROME (3-138): 1.1e-20: 90.3: 14.29
+	Sc
		701289 NYV1_YEAST (1-69): 2.67e-18: 76.8: 26.09		VAM7_YEAST (46-211): 1.29e-25: 103: 21.56
+	Sc
		611796 NYV1_YEAST (1-69): 2.67e-18: 76.8: 26.09		BET1_YEAST (93-235): 4.89e-27: 102: 18.06
+	Hs
		169416 VAMP7_HUMAN (1-74): 1.37e-19: 79.9: 39.19		BET1_HUMAN (149-234): 6.31e-25: 96.8: 18.61
+	Dm
		1178137 Q7JYX5_DROME (1-74): 9.14e-25: 93: 36.49		Q9VVX6_DROME (161-234): 4.68e-13: 65.7: 20.00
+	Dm
		577258 SYB_DROME (1-69): 2.94e-24: 89.9: 30.44		Q9VVX6_DROME (161-234): 4.68e-13: 65.7: 20.00