HitPredict

Interactor 1: NCKPL (P55160)
Nck-associated protein 1-like (Hematopoietic protein 1) (Membrane-associated protein HEM-1)
Gene: NCKAP1L

Interactor 2: ABI2 (Q9NYB9)
Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)
Gene: ABI2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Abi_HHR~Nckap1
Common GO terms	GO:0005829 - cytosol GO:0016477 - cell migration GO:0031209 - SCAR complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1127 Hs			1 513
+	Mm
		1208100 NCKPL_MOUSE (1-1127): 0: 1645: 94.85		ABI1_MOUSE (1-513): 2.82e-100: 312: 60.04
+	Mm
		659529 NCKP1_MOUSE (2-1122): 0: 1568: 59.05		ABI1_MOUSE (1-513): 2.82e-100: 312: 60.04
+	Hs
		1224661 NCKP1_HUMAN (2-1122): 0: 1574: 59.14		ABI1_HUMAN (1-513): 3.84e-97: 304: 61.00
+	Hs
		1348436 NCKP1_HUMAN (2-1122): 0: 1574: 59.14		ABI2_HUMAN (1-513): 1.82e-91: 290: 100.00
+	Dm
		876317 HEM_DROME (6-1122): 0: 1513: 47.68		Q9Y0S9_DROME (1-507): 5.88e-73: 240: 34.91
+	Mm
		659508 NCKP1_MOUSE (2-1122): 0: 1568: 59.05		ABI2_MOUSE (259-513): 1.38e-28: 119: 67.95
+	Hs
		924966 NCKP1_HUMAN (2-1122): 0: 1574: 59.14		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Mm
		1207370 Q8BVQ3_MOUSE (812-1127): 2.02e-151: 456: 95.57		ABI1_MOUSE (1-513): 2.82e-100: 312: 60.04