HitPredict

Interactor 1: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Interactor 2: RAP1A (P62834)
Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)
Gene: RAP1A

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.740

Property	Details
Experiments	10922060
Identification Methods	two hybrid, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	DIL~Ras, PDZ~Ras, RA~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030054 - cell junction GO:0031267 - small GTPase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1824 Hs			1 184
+	Hs
		486019 AFAD_HUMAN (1-1824): 0: 1279: 100.00		RAP2A_HUMAN (1-181): 3.65e-62: 192: 62.43
+	Hs
		876463 AFAD_HUMAN (1-1824): 0: 1279: 100.00		RIT1_HUMAN (2-180): 2.98e-56: 178: 48.37
+	Hs
		350005 AFAD_HUMAN (1-1824): 0: 1279: 100.00		RASK_HUMAN (1-184): 8.24e-56: 176: 54.45
+	Hs
		349224 AFAD_HUMAN (1-1824): 0: 1279: 100.00		RASH_HUMAN (1-180): 7.38e-55: 173: 55.00
+	Hs
		876485 AFAD_HUMAN (1-1824): 0: 1279: 100.00		RIT2_HUMAN (2-180): 1.67e-53: 171: 46.45
+	Dm
		442960 Q8IPP3_DROME (1-1732): 0: 876: 31.05		RAP1_DROME (1-166): 4.93e-83: 244: 89.76
+	Dm
		442967 Q95TT5_DROME (1-1642): 0: 835: 32.06		RAP1_DROME (1-166): 4.93e-83: 244: 89.76
+	Dm
		332203 Q8IPP3_DROME (1-1732): 0: 876: 31.05		O96692_DROME (1-181): 4.72e-60: 186: 56.91
+	Dm
		442999 Q8IPP3_DROME (1-1732): 0: 876: 31.05		RAS1_DROME (1-178): 8.95e-54: 171: 52.81
+	Dm
		332213 Q95TT5_DROME (1-1642): 0: 835: 32.06		O96692_DROME (1-181): 4.72e-60: 186: 56.91
+	Dm
		443003 Q95TT5_DROME (1-1642): 0: 835: 32.06		RAS1_DROME (1-178): 8.95e-54: 171: 52.81
+	Hs
		925728 MYO5B_HUMAN (102-939): 4.92e-118: 416: 14.72		RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08
+	Hs
		914453 MYO5B_HUMAN (102-939): 4.92e-118: 416: 14.72		RB11A_HUMAN (4-178): 2.1e-71: 216: 28.41
+	Hs
		1079976 MYO5B_HUMAN (102-939): 4.92e-118: 416: 14.72		RB11B_HUMAN (4-173): 1.69e-70: 214: 30.41
+	Rn
		914521 MYO5B_RAT (102-939): 4.23e-117: 413: 14.69		RB11A_RAT (4-178): 2.1e-71: 216: 28.41
+	Dm
		442954 Q24279_DROME (639-1315): 3.98e-97: 351: 38.74		RAP1_DROME (1-166): 4.93e-83: 244: 89.76
+	Hs
		486034 RAIN_HUMAN (244-982): 5.22e-96: 336: 16.01		RAP2A_HUMAN (1-181): 3.65e-62: 192: 62.43
+	Dm
		442992 Q24279_DROME (639-1315): 3.98e-97: 351: 38.74		RAS1_DROME (1-178): 8.95e-54: 171: 52.81
+	Hs
		349388 RAIN_HUMAN (244-982): 5.22e-96: 336: 16.01		RASH_HUMAN (1-180): 7.38e-55: 173: 55.00
+	Hs
		914346 KI13A_HUMAN (184-691): 2.35e-70: 264: 13.74		RB11A_HUMAN (4-178): 2.1e-71: 216: 28.41