HitPredict

Interactor 1: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	35271311, 36931259, 15161933
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1824 Hs			1 245
+	Hs
		876345 AFAD_HUMAN (1-1824): 0: 1279: 100.00		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		646752 AFAD_HUMAN (1-1824): 0: 1279: 100.00		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		683225 AFAD_HUMAN (1-1824): 0: 1279: 100.00		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		66892 A8MQ02_HUMAN (43-1824): 0: 1196: 99.44		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		66891 A8MQ02_HUMAN (43-1824): 0: 1196: 99.44		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		876343 AFAD_HUMAN (1-1824): 0: 1279: 100.00		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		876367 AFAD_HUMAN (1-1824): 0: 1279: 100.00		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		66890 A8MQ02_HUMAN (43-1824): 0: 1196: 99.44		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		927565 KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		910062 KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		647306 KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		683742 KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Dm
		54779 A1ZA18_DROME (184-689): 5.26e-62: 237: 13.76		1433Z_DROME (1-245): 3.35e-143: 402: 81.22
+	Dm
		54781 A1ZA18_DROME (184-689): 5.26e-62: 237: 13.76		1433E_DROME (2-242): 3.33e-143: 402: 66.67
+	Hs
		646906 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		905100 KI13A_HUMAN (184-691): 2.35e-70: 264: 13.74		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		684318 KI13A_HUMAN (184-691): 2.35e-70: 264: 13.74		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Hs
		905150 KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		982532 KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		684344 KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97