HitPredict

Interactor 1: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Interactor 2: NECT1 (Q15223)
Nectin-1 (Herpes virus entry mediator C) (Herpesvirus entry mediator C) (HveC) (Herpesvirus Ig-like receptor) (HIgR) (Nectin cell adhesion molecule 1) (Poliovirus receptor-related protein 1) (CD antigen CD111)
Gene: NECTIN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

Property	Details
Experiments	10225955, 15811349
Identification Methods	two hybrid, affinity chromatography technology, biochemical, pull down
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0007155 - cell adhesion GO:0044291 - cell-cell contact zone GO:0050839 - cell adhesion molecule binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1824 Hs			1 517
+	Hs
		876459 AFAD_HUMAN (1-1824): 0: 1279: 100.00		NECT2_HUMAN (27-406): 1.14e-69: 234: 31.82
+	Hs
		876471 AFAD_HUMAN (1-1824): 0: 1279: 100.00		NECT4_HUMAN (11-453): 5.58e-64: 218: 25.72
+	Hs
		876510 AFAD_HUMAN (1-1824): 0: 1279: 100.00		NECT3_HUMAN (24-517): 1.69e-62: 215: 29.03
+	Hs
		876467 AFAD_HUMAN (1-1824): 0: 1279: 100.00		KIRR1_HUMAN (29-489): 3.31e-35: 141: 13.74
+	Hs
		876457 AFAD_HUMAN (1-1824): 0: 1279: 100.00		TITIN_HUMAN (154-516): 9.68e-09: 60.5: 8.27
+	Mm
		1307920 PARD3_MOUSE (937-1811): 1.22e-20: 101: 11.59		NECT1_MOUSE (1-517): 6.6e-114: 348: 94.58
+	Mm
		1307921 PARD3_MOUSE (937-1811): 1.22e-20: 101: 11.59		NECT3_MOUSE (33-517): 3.56e-63: 217: 29.62
+	Dm
		113559 M9NFI9_DROME (1002-1092): 6.19e-22: 106: 38.95		Q9VQ08_DROME (194-517): 2.01e-32: 134: 12.02
+	Mm
		936319 DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51		DCC_MOUSE (234-515): 1.02e-21: 101: 11.73
+	Hs
		1077864 GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72		MYLK_HUMAN (129-243): 1.28e-10: 66.3: 9.57
+	Mm
		530208 DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51		NCAM1_MOUSE (28-429): 4.94e-19: 92.8: 13.38
+	Hs
		1050029 SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85		LRIG1_HUMAN (250-512): 5.72e-18: 89.8: 12.33
+	Dm
		52366 M9NFI9_DROME (1002-1092): 6.19e-22: 106: 38.95		A1Z7J1_DROME (44-321): 6.22e-15: 80.3: 18.40
+	Dm
		113767 M9NFI9_DROME (1002-1092): 6.19e-22: 106: 38.95		Q9W4T9_DROME (122-369): 4.25e-12: 71: 18.40
+	Hs
		1068678 PLEC_HUMAN (1384-1680): 9.8e-11: 69.6: 16.67		MXRA5_HUMAN (37-243): 1.22e-12: 72.8: 11.48
+	Hs
		1077872 MYO5A_HUMAN (1369-1800): 2.36e-11: 71.5: 10.74		MYLK_HUMAN (129-243): 1.28e-10: 66.3: 9.57