HitPredict

Interactor 1: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Interactor 2: SPD2A (Q5TCZ1)
SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains)
Gene: SH3PXD2A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27173435
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~SH3_2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1824 Hs			1 1133
+	Hs
		209019 AFAD_HUMAN (1-1824): 0: 1279: 100.00		NCK2_HUMAN (813-1029): 7.64e-17: 85.8: 18.65
+	Hs
		876420 AFAD_HUMAN (1-1824): 0: 1279: 100.00		DNMBP_HUMAN (790-1131): 3.26e-09: 63.6: 11.77
+	Hs
		1136549 KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64		SPD2A_HUMAN (1-1133): 5.76e-173: 541: 100.00
+	Hs
		231553 KIF1B_HUMAN (191-589): 6.21e-42: 171: 15.66		SPD2A_HUMAN (1-1133): 5.76e-173: 541: 100.00
+	Hs
		1020176 PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14		SPD2A_HUMAN (1-1133): 5.76e-173: 541: 100.00
+	Hs
		1256281 KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64		SH3R3_HUMAN (384-1130): 4.05e-32: 137: 11.21
+	Hs
		557789 KI13A_HUMAN (184-691): 2.35e-70: 264: 13.74		NCK1_HUMAN (272-569): 1.62e-23: 105: 14.64
+	Hs
		1066951 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		CD2AP_HUMAN (126-272): 6.38e-12: 71.7: 17.33
+	Hs
		1066506 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		SH3K1_HUMAN (270-877): 2.48e-09: 63.6: 11.75
+	Mm
		1143413 DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51		SH3R3_MOUSE (383-1130): 1.99e-30: 132: 9.49
+	Hs
		231661 KIF1B_HUMAN (191-589): 6.21e-42: 171: 15.66		SH3K1_HUMAN (270-877): 2.48e-09: 63.6: 11.75
+	Hs
		1020196 PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14		SH3R3_HUMAN (384-1130): 4.05e-32: 137: 11.21
+	Dm
		113458 M9NFI9_DROME (1002-1092): 6.19e-22: 106: 38.95		Q9VIF7_DROME (383-912): 1.31e-24: 113: 10.43
+	Mm
		223014 DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51		NCK2_MOUSE (372-603): 5.55e-15: 80.1: 11.79
+	Mm
		1143451 DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51		SH3K1_MOUSE (270-973): 1.19e-09: 64.8: 9.79
+	Hs
		1049703 SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85		ARHG7_HUMAN (744-985): 6.08e-10: 65.5: 14.62