HitPredict

Interactor 1: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Interactor 2: PKHA7 (Q6IQ23)
Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7)
Gene: PLEKHA7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FHA~PH, PH~RA
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0030054 - cell junction GO:0044331 - cell-cell adhesion mediated by cadherin GO:0046930 - pore complex and 1 others more... GO:0046931 - pore complex assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1824 Hs			1 1121
+	Hs
		876505 AFAD_HUMAN (1-1824): 0: 1279: 100.00		PKHA5_HUMAN (11-1074): 3.5e-95: 330: 29.45
+	Hs
		1153398 KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64		PKHA7_HUMAN (1-1121): 2.81e-180: 560: 100.00
+	Hs
		1334844 KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64		PKHA5_HUMAN (11-1074): 3.5e-95: 330: 29.45
+	Hs
		1331611 MYO5B_HUMAN (102-939): 4.92e-118: 416: 14.72		PKHA4_HUMAN (113-465): 8.31e-38: 154: 28.84
+	Hs
		876511 KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64		AFAD_HUMAN (329-1063): 1.33e-45: 182: 11.19
+	Hs
		876388 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		AFAD_HUMAN (329-1063): 1.33e-45: 182: 11.19
+	Hs
		1015789 KIF1A_HUMAN (183-586): 2.27e-62: 238: 15.40		PKHA4_HUMAN (113-465): 8.31e-38: 154: 28.84
+	Hs
		1066158 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		CYH1_HUMAN (105-281): 4.55e-43: 164: 21.69
+	Hs
		1066555 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		NED4L_HUMAN (59-486): 2.54e-26: 118: 12.47
+	Hs
		212312 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		CYH3_HUMAN (160-280): 1.5e-27: 118: 27.64
+	Mm
		1194486 DLG2_MOUSE (936-1143): 2.99e-34: 145: 24.55		CNKR2_MOUSE (119-516): 8.05e-46: 181: 17.87
+	Hs
		1056837 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		MDC1_HUMAN (281-1110): 6.34e-20: 98.8: 10.84
+	Hs
		231715 KIF1B_HUMAN (191-589): 6.21e-42: 171: 15.66		PKHA4_HUMAN (113-465): 8.31e-38: 154: 28.84
+	Hs
		1331350 GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72		PKHA4_HUMAN (113-465): 8.31e-38: 154: 28.84
+	Rn
		677809 DLG4_RAT (1002-1238): 9.23e-28: 123: 17.51		CNKR2_RAT (119-516): 4.49e-46: 182: 17.87
+	Mm
		1143379 DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51		CNKR2_MOUSE (119-516): 8.05e-46: 181: 17.87
+	Mm
		926281 DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51		CYH2_MOUSE (105-300): 1.44e-44: 168: 21.50
+	Hs
		231745 KIF1B_HUMAN (191-589): 6.21e-42: 171: 15.66		WWOX_HUMAN (9-115): 8.02e-20: 95.4: 29.91
+	Mm
		93273 DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51		E9PXB7_MOUSE (59-486): 2.89e-28: 125: 13.02
+	Mm
		140105 DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51		CYH3_MOUSE (160-280): 9.22e-27: 116: 27.64