HitPredict

Interactor 1: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 24255178
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FHA~Pkinase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1824 Hs			1 1088
+	Hs
		876412 AFAD_HUMAN (1-1824): 0: 1279: 100.00		MRCKA_HUMAN (656-1007): 6.11e-76: 277: 41.23
+	Hs
		876374 AFAD_HUMAN (1-1824): 0: 1279: 100.00		ROCK1_HUMAN (640-1008): 1.28e-70: 260: 38.77
+	Hs
		1295220 RADIL_HUMAN (830-1106): 4.06e-27: 122: 18.06		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		1020225 PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		1232910 LNX2_HUMAN (908-1089): 8.99e-18: 91.8: 18.13		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		325736 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325729 SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325709 PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Mm
		554913 DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51		KPCE_MOUSE (554-1010): 2.84e-130: 415: 29.92
+	Mm
		933108 DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51		KAPCB_MOUSE (638-1022): 3.87e-133: 409: 31.62
+	Ce
		88187 D3YT29_CAEEL (883-1284): 1.9e-19: 97.4: 16.63		WARTS_CAEEL (393-1050): 8.43e-135: 432: 35.98
+	Hs
		850715 GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72		KS6A3_HUMAN (519-990): 8.69e-81: 281: 19.63
+	Hs
		1073484 GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34
+	Mm
		1143553 DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51		KS6A2_MOUSE (519-973): 2.65e-79: 277: 19.79
+	Hs
		942348 DLG4_HUMAN (1002-1238): 1.07e-27: 123: 17.51		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34
+	Hs
		850651 SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85		KS6A3_HUMAN (519-990): 8.69e-81: 281: 19.63
+	Hs
		1049960 SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34
+	Hs
		1073494 NEB1_HUMAN (1002-1092): 1.04e-19: 98.7: 40.00		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34
+	Mm
		936586 DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51		ROCK2_MOUSE (640-1008): 1.72e-66: 247: 37.17
+	Dm
		113662 M9NFI9_DROME (1002-1092): 6.19e-22: 106: 38.95		Q9VXE3_DROME (611-1010): 5.98e-65: 243: 35.58