HitPredict

Interactor 1: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Interactor 2: FRM4B (Q9Y2L6)
FERM domain-containing protein 4B (GRP1-binding protein GRSP1)
Gene: FRMD4B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	34079125, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~RA
Common GO terms	GO:0005912 - adherens junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1824 Hs			1 1034
+	Hs
		876508 AFAD_HUMAN (1-1824): 0: 1279: 100.00		E41L5_HUMAN (29-740): 1.25e-143: 449: 17.36
+	Hs
		876371 AFAD_HUMAN (1-1824): 0: 1279: 100.00		PTN13_HUMAN (43-956): 2.9e-132: 444: 14.59
+	Hs
		876394 AFAD_HUMAN (1-1824): 0: 1279: 100.00		PTN14_HUMAN (62-1004): 2.37e-133: 434: 12.23
+	Dm
		51926 A1Z6Z9_DROME (102-924): 1.68e-103: 370: 14.56		MERH_DROME (52-668): 5.12e-120: 383: 18.62
+	Hs
		1066682 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		E41LB_HUMAN (40-899): 6.72e-151: 473: 12.86
+	Hs
		1020223 KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64		PTN13_HUMAN (43-956): 2.9e-132: 444: 14.59
+	Hs
		663980 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		PTN4_HUMAN (33-746): 2.73e-147: 464: 15.27
+	Hs
		1076927 KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64		PTN14_HUMAN (62-1004): 2.37e-133: 434: 12.23
+	Hs
		547066 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		EZRI_HUMAN (55-659): 1.36e-143: 444: 19.77
+	Hs
		719495 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		MERL_HUMAN (39-671): 5.01e-137: 427: 19.06
+	Hs
		719719 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		RADI_HUMAN (55-659): 4.07e-136: 424: 19.93
+	Hs
		640240 KIF1A_HUMAN (183-586): 2.27e-62: 238: 15.40		PTN3_HUMAN (33-739): 1.69e-125: 406: 17.50
+	Hs
		640106 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		MOES_HUMAN (55-659): 2.33e-128: 403: 20.59
+	Hs
		204669 KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67		E41L2_HUMAN (32-751): 1.52e-122: 401: 15.82
+	Dm
		136259 O01349_DROME (184-689): 5.04e-62: 237: 13.76		MERH_DROME (52-668): 5.12e-120: 383: 18.62
+	Dm
		54782 A1ZA18_DROME (184-689): 5.26e-62: 237: 13.76		MERH_DROME (52-668): 5.12e-120: 383: 18.62
+	Mm
		1143556 DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51		E41L3_MOUSE (51-780): 1.8e-131: 422: 16.16
+	Mm
		1143533 DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51		E41LB_MOUSE (40-466): 2.74e-124: 391: 17.56
+	Dm
		1098283 PATJ_DROME (969-1164): 1.83e-29: 129: 28.08		MERH_DROME (52-668): 5.12e-120: 383: 18.62
+	Dm
		802985 PATJ_DROME (969-1164): 1.83e-29: 129: 28.08		MOEH_DROME (56-659): 7.37e-119: 378: 17.75