HitPredict

Interactor 1: BRPF1 (P55201)
Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140)
Gene: BRPF1

Interactor 2: H2B1C (P62807)
Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)
Gene: H2BC4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 34349018
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~PWWP
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1214 Hs			1 126
+	Hs
		617938 BRPF1_HUMAN (1-1214): 0: 1189: 100.00		H2B1O_HUMAN (1-126): 2.88e-54: 167: 98.41
+	Hs
		876694 BRPF1_HUMAN (1-1214): 0: 1189: 100.00		H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21
+	Hs
		617986 BRPF3_HUMAN (58-1211): 0: 911: 48.70		H2B1O_HUMAN (1-126): 2.88e-54: 167: 98.41
+	Hs
		1087475 BRPF3_HUMAN (58-1211): 0: 911: 48.70		H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21
+	Hs
		319121 BRD1_HUMAN (62-1214): 0: 778: 44.59		H2B1O_HUMAN (1-126): 2.88e-54: 167: 98.41
+	Hs
		319162 BRD1_HUMAN (62-1214): 0: 778: 44.59		H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00
+	Hs
		319214 BRD1_HUMAN (62-1214): 0: 778: 44.59		H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21
+	Hs
		617953 JADE1_HUMAN (74-656): 7.35e-135: 434: 25.83		H2B1O_HUMAN (1-126): 2.88e-54: 167: 98.41
+	Hs
		1087195 JADE1_HUMAN (74-656): 7.35e-135: 434: 25.83		H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21
+	Hs
		617982 JADE2_HUMAN (71-641): 3.11e-120: 393: 26.08		H2B1O_HUMAN (1-126): 2.88e-54: 167: 98.41
+	Hs
		617963 JADE3_HUMAN (73-656): 1.19e-118: 389: 25.21		H2B1O_HUMAN (1-126): 2.88e-54: 167: 98.41
+	Hs
		1087304 JADE3_HUMAN (73-656): 1.19e-118: 389: 25.21		H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21
+	Hs
		918569 JADE3_HUMAN (73-656): 1.19e-118: 389: 25.21		H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00
+	Sc
		356046 NTO1_YEAST (119-698): 3.26e-123: 399: 25.45		H2B2_YEAST (3-125): 5.51e-37: 124: 71.55
+	Sc
		355691 NTO1_YEAST (119-698): 3.26e-123: 399: 25.45		H2B1_YEAST (3-125): 1.92e-36: 122: 71.55
+	Hs
		301133 KDM4B_HUMAN (86-464): 9e-76: 275: 22.72		H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00
+	Hs
		876570 AF10_HUMAN (270-581): 3.68e-65: 242: 30.12		H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21
+	Hs
		1087293 PHIP_HUMAN (425-1054): 9.63e-64: 240: 13.84		H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21
+	Hs
		918554 PHIP_HUMAN (425-1054): 9.63e-64: 240: 13.84		H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00
+	Hs
		876585 AF17_HUMAN (270-521): 3.76e-60: 227: 34.07		H2BFS_HUMAN (1-126): 1.03e-53: 166: 97.62