HitPredict

Interactor 1: CASP6 (P55212)
Caspase-6 (CASP-6) (CSP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18 (Caspase-6 subunit p20); Caspase-6 subunit p11 (Caspase-6 subunit p10)]
Gene: CASP6

Interactor 2: TRAF1 (Q13077)
TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)
Gene: TRAF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11098060
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006915 - apoptotic process
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 293 Hs			1 416
+	Hs
		788250 CASP2_HUMAN (37-291): 7.54e-100: 301: 29.12		TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00
+	Hs
		1023660 CASP8_HUMAN (5-289): 3.37e-98: 298: 30.20		TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00
+	Mm
		669121 CASP2_MOUSE (5-291): 1.85e-99: 300: 26.16		TRAF1_MOUSE (1-416): 4.49e-160: 458: 84.38
+	Hs
		1023744 CASPA_HUMAN (12-238): 6.22e-75: 239: 32.75		TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00
+	Hs
		181606 CFLAR_HUMAN (16-279): 5.47e-71: 228: 22.38		TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00
+	Hs
		876940 CASP7_HUMAN (33-288): 3.89e-113: 330: 38.28		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Mm
		669122 CASP2_MOUSE (5-291): 1.85e-99: 300: 26.16		TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77
+	Hs
		788249 CASP2_HUMAN (37-291): 7.54e-100: 301: 29.12		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		1020664 CASP8_HUMAN (5-289): 3.37e-98: 298: 30.20		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		667455 CASP1_HUMAN (11-291): 1.32e-98: 296: 23.89		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		1020747 CASPC_HUMAN (48-292): 2.25e-84: 258: 21.65		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		830308 CASP4_HUMAN (5-292): 7.2e-101: 301: 23.30		TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98
+	Hs
		1059404 CASP8_HUMAN (5-289): 3.37e-98: 298: 30.20		TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98
+	Mm
		292696 CASP8_MOUSE (4-290): 6.14e-99: 300: 32.48		TRAF6_MOUSE (15-414): 1.94e-101: 313: 22.51
+	Hs
		181605 CFLAR_HUMAN (16-279): 5.47e-71: 228: 22.38		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		788188 CASP3_HUMAN (37-289): 1.09e-110: 323: 41.90		TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77
+	Hs
		788251 CASP2_HUMAN (37-291): 7.54e-100: 301: 29.12		TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77
+	Hs
		181607 CFLAR_HUMAN (16-279): 5.47e-71: 228: 22.38		TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77