HitPredict

Interactor 1: D0VY79 (D0VY79)
Hypoxia-inducible factor 1-alpha
Gene: HIF1A

Interactor 2: BMAL1 (O00327)
Basic helix-loop-helix ARNT-like protein 1 (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Basic-helix-loop-helix-PAS protein MOP3) (Brain and muscle ARNT-like 1) (Class E basic helix-loop-helix protein 5) (bHLHe5) (Member of PAS protein 3) (PAS domain-containing protein 3) (bHLH-PAS protein JAP3)
Gene: BMAL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HLH~PAS, PAS~PAS, PAS~PAS_11, PAS~PAS_3, PAS_11~PAS_3
Common GO terms	GO:0005654 - nucleoplasm GO:0032007 - negative regulation of TOR signaling GO:0070888 - E-box binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 826 Hs			1 626
+	Hs
		126132 HIF1A_HUMAN (1-826): 0: 741: 100.00		BMAL1_HUMAN (1-626): 0: 668: 100.00
+	Mm
		1142409 HIF1A_MOUSE (1-826): 0: 706: 87.63		BMAL1_MOUSE (1-626): 0: 665: 97.00
+	Hs
		1085741 HIF1A_HUMAN (1-826): 0: 741: 100.00		X5DP31_HUMAN (9-601): 1.4e-154: 461: 32.01
+	Hs
		649123 HIF1A_HUMAN (1-826): 0: 741: 100.00		ARNT_HUMAN (29-576): 2.06e-151: 457: 33.16
+	Hs
		1085690 HIF1A_HUMAN (1-826): 0: 741: 100.00		ARNT2_HUMAN (9-606): 2.15e-149: 450: 32.24
+	Hs
		126166 EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24		BMAL1_HUMAN (1-626): 0: 668: 100.00
+	Mm
		956582 EPAS1_MOUSE (4-824): 5.43e-165: 503: 40.91		BMAL1_MOUSE (1-626): 0: 665: 97.00
+	Hs
		1085655 HIF1A_HUMAN (1-826): 0: 741: 100.00		EPAS1_HUMAN (64-623): 1.87e-132: 411: 21.83
+	Mm
		864794 HIF1A_MOUSE (1-826): 0: 706: 87.63		ARNT_MOUSE (29-594): 9.93e-147: 445: 33.39
+	Hs
		1085577 HIF1A_HUMAN (1-826): 0: 741: 100.00		HIF1A_HUMAN (64-623): 1.41e-128: 400: 19.53
+	Hs
		1085730 HIF1A_HUMAN (1-826): 0: 741: 100.00		HIF3A_HUMAN (62-623): 6.54e-102: 325: 17.79
+	Hs
		1264408 EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24		BMAL2_HUMAN (8-626): 0: 530: 48.21
+	Mm
		1012216 HIF1A_MOUSE (1-826): 0: 706: 87.63		HIF3A_MOUSE (50-623): 9.27e-101: 322: 17.94
+	Hs
		649150 EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24		ARNT_HUMAN (29-576): 2.06e-151: 457: 33.16
+	Hs
		1306541 EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24		ARNT2_HUMAN (9-606): 2.15e-149: 450: 32.24
+	Mm
		864790 EPAS1_MOUSE (4-824): 5.43e-165: 503: 40.91		ARNT_MOUSE (29-594): 9.93e-147: 445: 33.39
+	Hs
		1306527 EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24		EPAS1_HUMAN (64-623): 1.87e-132: 411: 21.83
+	Hs
		1306557 EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24		HIF3A_HUMAN (62-623): 6.54e-102: 325: 17.79
+	Mm
		956580 EPAS1_MOUSE (4-824): 5.43e-165: 503: 40.91		HIF3A_MOUSE (50-623): 9.27e-101: 322: 17.94