HitPredict

Interactor 1: FOXA1 (P55317)
Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A)
Gene: FOXA1

Interactor 2: KMT2C (Q8NEZ4)
Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)
Gene: KMT2C

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27926873
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 472 Hs			1 4911
+	Hs
		1021323 FOXL1_HUMAN (143-337): 1.76e-55: 190: 42.86		KMT2C_HUMAN (1-4911): 0: 2416: 100.00
+	Hs
		1021235 FOXI1_HUMAN (113-372): 1.78e-46: 167: 28.93		KMT2C_HUMAN (1-4911): 0: 2416: 100.00
+	Hs
		877733 FOXA1_HUMAN (1-472): 5.65e-93: 291: 100.00		CHD4_HUMAN (83-436): 3.08e-38: 161: 13.56
+	Hs
		877716 FOXA1_HUMAN (1-472): 5.65e-93: 291: 100.00		CHD3_HUMAN (390-526): 1.86e-31: 139: 21.38
+	Hs
		877612 FOXG1_HUMAN (17-470): 1.3e-61: 210: 22.32		CHD4_HUMAN (83-436): 3.08e-38: 161: 13.56
+	Hs
		1021109 FOXC1_HUMAN (130-457): 7.84e-49: 177: 31.42		CHD4_HUMAN (83-436): 3.08e-38: 161: 13.56
+	Hs
		964181 FOXK2_HUMAN (67-472): 2.52e-43: 163: 20.69		CHD4_HUMAN (83-436): 3.08e-38: 161: 13.56
+	Hs
		1059853 FOXQ1_HUMAN (69-459): 1.06e-43: 160: 24.75		CHD4_HUMAN (83-436): 3.08e-38: 161: 13.56
+	Hs
		964284 FOXK2_HUMAN (67-472): 2.52e-43: 163: 20.69		SET1B_HUMAN (4778-4911): 3.56e-24: 115: 51.11
+	Hs
		952846 FOXK1_HUMAN (107-373): 2.04e-54: 195: 27.24		REQU_HUMAN (359-435): 2.72e-12: 74.3: 41.25
+	Hs
		152638 FOXL1_HUMAN (143-337): 1.76e-55: 190: 42.86		KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82
+	Hs
		1021240 FOXI1_HUMAN (113-372): 1.78e-46: 167: 28.93		DPF1_HUMAN (350-435): 3.04e-13: 77: 40.45
+	Hs
		1021241 FOXI1_HUMAN (113-372): 1.78e-46: 167: 28.93		REQU_HUMAN (359-435): 2.72e-12: 74.3: 41.25
+	Hs
		152637 FOXI1_HUMAN (113-372): 1.78e-46: 167: 28.93		KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82
+	Hs
		964282 FOXK2_HUMAN (67-472): 2.52e-43: 163: 20.69		KMT2B_HUMAN (1985-2617): 4.3e-09: 65.8: 12.11
+	Hs
		152626 FOXK2_HUMAN (67-472): 2.52e-43: 163: 20.69		KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82