HitPredict

Interactor 1: SEC13 (P55735)
Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein)
Gene: SEC13

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome GO:1904263 - positive regulation of TORC1 signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 322 Hs			1 768
+	Hs
		1042655 NLE1_HUMAN (196-317): 5.64e-28: 114: 20.49		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1041647 TAF5_HUMAN (171-320): 7.18e-23: 101: 14.61		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		878180 SEC13_HUMAN (1-322): 1.89e-85: 261: 100.00		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1042101 POC1B_HUMAN (2-95): 2.54e-19: 89.8: 29.79		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		152875 APAF_HUMAN (12-134): 4.76e-11: 65.9: 21.71		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		903207 WDR5_HUMAN (249-320): 1.4e-10: 63.3: 16.67		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1043499 FBXW7_HUMAN (87-316): 1.49e-41: 154: 14.72		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1043085 WDR5B_HUMAN (2-194): 1.22e-31: 122: 16.67		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1043441 WDR5B_HUMAN (2-194): 1.22e-31: 122: 16.67		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1043157 SNR40_HUMAN (3-131): 4.97e-25: 104: 22.22		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		792982 LIS1_HUMAN (208-320): 5.26e-24: 102: 20.35		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1043509 SNR40_HUMAN (3-131): 4.97e-25: 104: 22.22		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1043114 POC1B_HUMAN (2-95): 2.54e-19: 89.8: 29.79		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1043469 POC1B_HUMAN (2-95): 2.54e-19: 89.8: 29.79		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Mm
		1257398 FBXW7_MOUSE (87-316): 5.76e-42: 156: 14.72		CUL1_MOUSE (17-768): 0: 709: 30.53
+	Hs
		1041133 FBXW7_HUMAN (87-316): 1.49e-41: 154: 14.72		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		903208 WDR5_HUMAN (249-320): 1.4e-10: 63.3: 16.67		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		152876 APAF_HUMAN (12-134): 4.76e-11: 65.9: 21.71		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		903209 WDR5_HUMAN (249-320): 1.4e-10: 63.3: 16.67		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		903206 WDR5_HUMAN (249-320): 1.4e-10: 63.3: 16.67		CUL1_HUMAN (18-768): 0: 707: 30.57