HitPredict

Interactor 1: SEC13 (P55735)
Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein)
Gene: SEC13

Interactor 2: GRWD1 (Q9BQ67)
Glutamate-rich WD repeat-containing protein 1
Gene: GRWD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CAF1C_H4-bd~WD40, WD40~WD40
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 322 Hs			1 446
+	Hs
		1202778 WDR5B_HUMAN (2-194): 1.22e-31: 122: 16.67		GRWD1_HUMAN (1-446): 4.56e-121: 361: 100.00
+	Hs
		1288270 SNR40_HUMAN (3-131): 4.97e-25: 104: 22.22		GRWD1_HUMAN (1-446): 4.56e-121: 361: 100.00
+	Hs
		878165 SEC13_HUMAN (1-322): 1.89e-85: 261: 100.00		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	At
		1164331 TAF5_ARATH (7-281): 1.13e-36: 141: 21.60		TAF5_ARATH (148-445): 3.86e-62: 214: 19.93
+	Hs
		878196 SEC13_HUMAN (1-322): 1.89e-85: 261: 100.00		WDR59_HUMAN (259-382): 1.24e-12: 72: 28.23
+	Dm
		1358845 WDS_DROME (90-319): 1.09e-47: 165: 19.57		WDS_DROME (248-445): 1.19e-46: 166: 21.21
+	Hs
		903418 FBXW7_HUMAN (87-316): 1.49e-41: 154: 14.72		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	Hs
		903349 WDR5B_HUMAN (2-194): 1.22e-31: 122: 16.67		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	Hs
		903551 NLE1_HUMAN (196-317): 5.64e-28: 114: 20.49		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	Sp
		999838 TUP11_SCHPO (2-250): 9.63e-58: 198: 20.93		TUP11_SCHPO (62-182): 4.7e-15: 79.2: 7.97
+	Hs
		1240442 POC1B_HUMAN (2-95): 2.54e-19: 89.8: 29.79		POC1A_HUMAN (208-445): 1.16e-53: 186: 15.97
+	Hs
		903428 SNR40_HUMAN (3-131): 4.97e-25: 104: 22.22		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	Hs
		792949 LIS1_HUMAN (208-320): 5.26e-24: 102: 20.35		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	Mm
		925836 LIS1_MOUSE (208-320): 4.41e-24: 103: 20.35		LIS1_MOUSE (243-445): 5.09e-42: 155: 17.00
+	Hs
		792935 LIS1_HUMAN (208-320): 5.26e-24: 102: 20.35		LIS1_HUMAN (243-445): 6.45e-42: 155: 17.00
+	Hs
		1083339 FBXW7_HUMAN (87-316): 1.49e-41: 154: 14.72		RBBP7_HUMAN (66-247): 3.57e-20: 94.3: 10.42
+	Ce
		954080 SEC13_CAEEL (100-321): 1.03e-31: 122: 21.40		LIN53_CAEEL (41-247): 1.86e-21: 97.7: 10.33
+	Hs
		793026 LIS1_HUMAN (208-320): 5.26e-24: 102: 20.35		KTNB1_HUMAN (55-289): 7.58e-23: 103: 15.98
+	Hs
		1346954 NLE1_HUMAN (196-317): 5.64e-28: 114: 20.49		NLE1_HUMAN (338-445): 4.67e-18: 88.1: 13.89
+	Hs
		1074780 TAF5_HUMAN (171-320): 7.18e-23: 101: 14.61		TAF5_HUMAN (297-445): 3.11e-19: 92.4: 11.44