HitPredict

Interactor 1: D2IYK1 (D2IYK1)
HLA class I histocompatibility antigen B alpha chain (MHC class I antigen) (MHC class I protein)
Gene: HLA-B

Interactor 2: KI2L2 (P43627)
Killer cell immunoglobulin-like receptor 2DL2 (CD158 antigen-like family member B1) (Natural killer-associated transcript 6) (NKAT-6) (p58 natural killer cell receptor clone CL-43) (p58 NK receptor CL-43) (CD antigen CD158b1)
Gene: KIR2DL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	18322206
Identification Methods	affinity chromatography technology
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1-set~ig, MHC_I~ig
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 362 Hs			1 348
+	Hs
		798173 Q5RIP0_HUMAN (1-362): 5.05e-167: 472: 87.60		KI2L2_HUMAN (1-348): 1.32e-134: 388: 100.00
+	Hs
		798148 Q5RIP0_HUMAN (1-362): 5.05e-167: 472: 87.60		KI2L1_HUMAN (1-348): 1.05e-132: 384: 94.54
+	Hs
		798171 Q5D1W8_HUMAN (1-362): 7.73e-165: 466: 86.50		KI2L2_HUMAN (1-348): 1.32e-134: 388: 100.00
+	Hs
		798146 Q5D1W8_HUMAN (1-362): 7.73e-165: 466: 86.50		KI2L1_HUMAN (1-348): 1.05e-132: 384: 94.54
+	Hs
		382484 HLAA_HUMAN (1-362): 7.39e-178: 499: 86.46		LIRB4_HUMAN (1-324): 1.6e-77: 246: 29.20
+	Hs
		1060406 Q95J06_HUMAN (1-362): 0: 510: 84.53		KI3S1_HUMAN (1-346): 8.59e-72: 229: 31.23
+	Hs
		382420 HLAA_HUMAN (1-362): 7.39e-178: 499: 86.46		KI3S1_HUMAN (1-346): 8.59e-72: 229: 31.23
+	Hs
		1060403 Q5SUL5_HUMAN (1-362): 9.11e-176: 494: 84.53		KI3S1_HUMAN (1-346): 8.59e-72: 229: 31.23
+	Hs
		47499 HLAA_HUMAN (1-362): 7.39e-178: 499: 86.46		A0A8I5QEB2_HUMAN (1-330): 3.52e-69: 224: 33.93
+	Hs
		382341 HLAA_HUMAN (1-362): 7.39e-178: 499: 86.46		KI3L2_HUMAN (1-347): 6.49e-68: 222: 32.57
+	Hs
		798244 Q5S3G3_HUMAN (1-362): 1.5e-177: 498: 86.74		KI3L2_HUMAN (1-347): 6.49e-68: 222: 32.57
+	Hs
		1232786 Q95J06_HUMAN (1-362): 0: 510: 84.53		LIRB2_HUMAN (17-348): 2.58e-53: 186: 28.70
+	Hs
		1245576 Q95J06_HUMAN (1-362): 0: 510: 84.53		LIRB1_HUMAN (17-348): 3.13e-51: 182: 28.41
+	Hs
		382478 HLAA_HUMAN (1-362): 7.39e-178: 499: 86.46		LIRB2_HUMAN (17-348): 2.58e-53: 186: 28.70
+	Hs
		1130837 Q5S3G3_HUMAN (1-362): 1.5e-177: 498: 86.74		LIRB2_HUMAN (17-348): 2.58e-53: 186: 28.70
+	Hs
		382485 HLAA_HUMAN (1-362): 7.39e-178: 499: 86.46		LIRB1_HUMAN (17-348): 3.13e-51: 182: 28.41
+	Hs
		1130838 Q5S3G3_HUMAN (1-362): 1.5e-177: 498: 86.74		LIRB1_HUMAN (17-348): 3.13e-51: 182: 28.41
+	Hs
		798195 Q5S3G3_HUMAN (1-362): 1.5e-177: 498: 86.74		KI2L3_HUMAN (124-346): 1.24e-29: 118: 24.78
+	Hs
		798280 Q5S3G3_HUMAN (1-362): 1.5e-177: 498: 86.74		KI2S4_HUMAN (124-346): 4.29e-29: 115: 24.78
+	Hs
		798194 Q5RIP0_HUMAN (1-362): 5.05e-167: 472: 87.60		KI2L3_HUMAN (124-346): 1.24e-29: 118: 24.78