HitPredict

Interactor 1: SUMO3 (P55854)
Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A)
Gene: SUMO3

Interactor 2: PIAS4 (Q8N2W9)
E3 SUMO-protein ligase PIAS4 (EC 2.3.2.27) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma)
Gene: PIAS4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	15383276
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Rad60-SLD~zf-MIZ
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016605 - PML body GO:0016925 - protein sumoylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 103 Hs			1 510
+	Hs
		902668 SUMO2_HUMAN (1-93): 4.15e-41: 132: 96.81		PIAS4_HUMAN (1-510): 0: 670: 100.00
+	Hs
		928135 SUMO1_HUMAN (1-92): 2.47e-36: 120: 48.45		PIAS4_HUMAN (1-510): 0: 670: 100.00
+	Rn
		78200 SUMO3_RAT (1-97): 6.47e-45: 142: 94.85		B5DFF9_RAT (1-510): 0: 628: 87.96
+	Rn
		78199 SUMO1_RAT (1-92): 2.47e-36: 120: 48.45		B5DFF9_RAT (1-510): 0: 628: 87.96
+	Hs
		879167 SUMO3_HUMAN (1-103): 1.24e-48: 151: 100.00		PIAS3_HUMAN (3-509): 0: 540: 46.59
+	Hs
		278009 SUMO3_HUMAN (1-103): 1.24e-48: 151: 100.00		PIAS1_HUMAN (3-508): 2.66e-180: 522: 46.42
+	Hs
		902827 SUMO2_HUMAN (1-93): 4.15e-41: 132: 96.81		PIAS3_HUMAN (3-509): 0: 540: 46.59
+	Hs
		278250 SUMO3_HUMAN (1-103): 1.24e-48: 151: 100.00		PIAS2_HUMAN (3-504): 9.32e-180: 520: 44.74
+	Rn
		1140374 SUMO3_RAT (1-97): 6.47e-45: 142: 94.85		PIAS2_RAT (3-504): 0: 522: 44.74
+	Mm
		222291 SUMO1_MOUSE (1-92): 2.47e-36: 120: 48.45		PIAS3_MOUSE (3-509): 0: 541: 46.20
+	Hs
		928241 SUMO1_HUMAN (1-92): 2.47e-36: 120: 48.45		PIAS3_HUMAN (3-509): 0: 540: 46.59
+	Hs
		278020 SUMO2_HUMAN (1-93): 4.15e-41: 132: 96.81		PIAS1_HUMAN (3-508): 2.66e-180: 522: 46.42
+	Hs
		278253 SUMO2_HUMAN (1-93): 4.15e-41: 132: 96.81		PIAS2_HUMAN (3-504): 9.32e-180: 520: 44.74
+	Hs
		278040 SUMO1_HUMAN (1-92): 2.47e-36: 120: 48.45		PIAS1_HUMAN (3-508): 2.66e-180: 522: 46.42
+	Hs
		278256 SUMO1_HUMAN (1-92): 2.47e-36: 120: 48.45		PIAS2_HUMAN (3-504): 9.32e-180: 520: 44.74
+	Dm
		332592 O97102_DROME (6-94): 4.45e-39: 127: 69.66		Q9XYM5_DROME (11-461): 2.02e-143: 424: 40.08
+	At
		1147334 SUMO2_ARATH (1-98): 1.43e-41: 133: 47.96		SIZ1_ARATH (8-415): 4.87e-80: 269: 20.65
+	At
		1147333 SUMO3_ARATH (1-96): 2.22e-37: 123: 40.21		SIZ1_ARATH (8-415): 4.87e-80: 269: 20.65
+	Rn
		89025 SUMO3_RAT (1-97): 6.47e-45: 142: 94.85		D4AE97_RAT (73-419): 3.81e-71: 247: 23.42
+	At
		878961 SUMO1_ARATH (2-90): 1.01e-35: 118: 47.19		SIZ1_ARATH (8-415): 4.87e-80: 269: 20.65