HitPredict

Interactor 1: BID (P55957)
BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)]
Gene: BID

Interactor 2: B2LA1 (Q16548)
Bcl-2-related protein A1 (Bcl-2-like protein 5) (Bcl2-L-5) (Hemopoietic-specific early response protein) (Protein BFL-1) (Protein GRS)
Gene: BCL2A1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.768

The method score is based on:

Property Details
Experiments 16697956, 11929871
Identification Methods unspecified method, affinity chromatography technology, fluorescence polarization spectroscopy
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains BID~Bcl-2
Common GO terms GO:0001836 - release of cytochrome c from mitochondria
GO:0005741 - mitochondrial outer membrane
GO:0005829 - cytosol
GO:0043065 - positive regulation of apoptotic process
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 195
Hs

1 175
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024