HitPredict

Interactor 1: RRP1 (P56182)
Ribosomal RNA processing protein 1 homolog A (Novel nuclear protein 1) (NNP-1) (Nucleolar protein Nop52) (RRP1-like protein)
Gene: RRP1

Interactor 2: SRPK2 (P78362)
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
Gene: SRPK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	26167880, 32707033
Identification Methods	enzymatic study, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005730 - nucleolus
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 461 Hs			1 688
+	Hs
		942661 RRP1B_HUMAN (1-461): 0: 535: 45.14		SRPK2_HUMAN (12-688): 3.2e-128: 397: 95.66
+	Hs
		1057598 RRP1B_HUMAN (1-461): 0: 535: 45.14		SRPK1_HUMAN (27-688): 1.57e-125: 388: 53.22
+	Hs
		1057468 RRP1B_HUMAN (1-461): 0: 535: 45.14		KS6A2_HUMAN (2-372): 3.86e-77: 263: 15.21
+	Hs
		1057708 RRP1B_HUMAN (1-461): 0: 535: 45.14		KS6A6_HUMAN (2-362): 5.53e-77: 263: 15.92
+	Hs
		880071 RRP1_HUMAN (1-461): 0: 552: 100.00		SRPK3_HUMAN (450-687): 1.19e-63: 223: 66.39
+	Hs
		834009 RRP1_HUMAN (1-461): 0: 552: 100.00		CLK3_HUMAN (62-240): 6.66e-62: 220: 31.11
+	Hs
		1057726 RRP1B_HUMAN (1-461): 0: 535: 45.14		SRPK3_HUMAN (450-687): 1.19e-63: 223: 66.39
+	Hs
		834042 RRP1B_HUMAN (1-461): 0: 535: 45.14		CLK3_HUMAN (62-240): 6.66e-62: 220: 31.11
+	Hs
		272865 RRP1B_HUMAN (1-461): 0: 535: 45.14		KS6A4_HUMAN (3-378): 1.53e-33: 139: 16.17