HitPredict

Interactor 1: AP1S2 (P56377)
AP-1 complex subunit sigma-2 (Adaptor protein complex AP-1 subunit sigma-1B) (Adaptor-related protein complex 1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin)
Gene: AP1S2

Interactor 2: AP2B1 (P63010)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	33961781, 26496610, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Adaptin_N~Clat_adaptor_s
Common GO terms	GO:0005829 - cytosol GO:0006886 - intracellular protein transport GO:0016192 - vesicle-mediated transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 157 Hs			1 937
+	Hs
		903681 AP1S1_HUMAN (1-157): 6.65e-55: 171: 87.26		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Hs
		925978 AP1S3_HUMAN (1-153): 9.56e-49: 155: 71.24		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Hs
		925992 AP1M1_HUMAN (2-153): 2.63e-43: 149: 19.23		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Hs
		880409 AP1S2_HUMAN (1-157): 3.42e-55: 172: 100.00		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Hs
		903682 AP1S1_HUMAN (1-157): 6.65e-55: 171: 87.26		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Hs
		1014066 AP1S3_HUMAN (1-153): 9.56e-49: 155: 71.24		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Hs
		1014074 AP1M1_HUMAN (2-153): 2.63e-43: 149: 19.23		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Zm
		30064 Q9MAY9_MAIZE (1-154): 9.2e-45: 146: 18.35		A0A1D6K3D9_MAIZE (41-936): 0: 711: 55.28
+	Hs
		120009 AP3S1_HUMAN (1-143): 5.8e-49: 157: 36.91		AP3B1_HUMAN (8-594): 5.76e-178: 547: 28.17
+	Hs
		119942 AP3S2_HUMAN (1-143): 4.58e-47: 153: 36.91		AP3B1_HUMAN (8-594): 5.76e-178: 547: 28.17
+	Hs
		212611 AP1S2_HUMAN (1-157): 3.42e-55: 172: 100.00		AP1G1_HUMAN (11-808): 1.03e-173: 527: 17.57
+	Hs
		212614 AP1S1_HUMAN (1-157): 6.65e-55: 171: 87.26		AP1G1_HUMAN (11-808): 1.03e-173: 527: 17.57
+	Hs
		1032730 AP3S1_HUMAN (1-143): 5.8e-49: 157: 36.91		AP3B2_HUMAN (16-594): 2.55e-174: 537: 28.71
+	Hs
		212659 AP1S3_HUMAN (1-153): 9.56e-49: 155: 71.24		AP1G1_HUMAN (11-808): 1.03e-173: 527: 17.57
+	Hs
		1377945 AP4S1_HUMAN (1-143): 6.01e-47: 151: 36.36		AP4B1_HUMAN (15-628): 3.34e-176: 530: 29.63
+	Mm
		612130 AP1M1_MOUSE (2-153): 2.42e-43: 149: 19.23		AP1G1_MOUSE (11-808): 1.8e-174: 529: 17.57
+	Hs
		212662 AP1M1_HUMAN (2-153): 2.63e-43: 149: 19.23		AP1G1_HUMAN (11-808): 1.03e-173: 527: 17.57
+	Hs
		276360 AP1S2_HUMAN (1-157): 3.42e-55: 172: 100.00		AP1G2_HUMAN (11-698): 4e-162: 496: 14.73
+	Hs
		276362 AP1S1_HUMAN (1-157): 6.65e-55: 171: 87.26		AP1G2_HUMAN (11-698): 4e-162: 496: 14.73
+	Hs
		276385 AP1S3_HUMAN (1-153): 9.56e-49: 155: 71.24		AP1G2_HUMAN (11-698): 4e-162: 496: 14.73