HitPredict

Interactor 1: AP1S2 (P56377)
AP-1 complex subunit sigma-2 (Adaptor protein complex AP-1 subunit sigma-1B) (Adaptor-related protein complex 1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin)
Gene: AP1S2

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned1853
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 157 Hs			1 2527
+	Hs
		70334 B2R4I8_HUMAN (1-143): 1.26e-48: 156: 37.58		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1123868 Q59EK3_HUMAN (2-153): 2.01e-44: 153: 19.23		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130425 AP2M1_HUMAN (1-153): 7.95e-41: 143: 16.23		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		101669 F8VVA7_HUMAN (1-154): 6.45e-40: 135: 17.51		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		945779 AP2M1_HUMAN (1-153): 7.95e-41: 143: 16.23		M3K9_HUMAN (1874-2136): 3.07e-24: 114: 32.38