HitPredict

Interactor 1: CLR3 (P56523)
Histone deacetylase clr3 (EC 3.5.1.98) (Cryptic loci regulator 3)
Gene: CLR3

Interactor 2: CLR3 (P56523)
Histone deacetylase clr3 (EC 3.5.1.98) (Cryptic loci regulator 3)
Gene: CLR3

Species: Schizosaccharomyces pombe 972h-

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 1.00 0.845

The method score is based on:

Property Details
Experiments 26771498, 27105116, 23695164
Identification Methods two hybrid, x-ray crystallography, two hybrid array
Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Arb2~Arb2, Arb2~Hist_deacetyl, Hist_deacetyl~Hist_deacetyl
Common GO terms GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000183 - rDNA heterochromatin formation
GO:0000785 - chromatin
GO:0004407 - histone deacetylase activity
and 16 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 687
Sp

1 687
+ Sc
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
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+ Mm
+ Hs
+ Hs
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+ Mm
+ Rn
+ Mm
+ Hs
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+ Mm

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Last updated: 15 Jul 2024