Interactor 1: HDAC4 (P56524)
Histone deacetylase 4 (HD4) (EC 3.5.1.98)
Gene: HDAC4

Interactor 2: HDAC4 (P56524)
Histone deacetylase 4 (HD4) (EC 3.5.1.98)
Gene: HDAC4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 1.00 0.925

The method score is based on:

Property Details
Experiments 11486037, 31040226, 18332106, 23752268, 17360518
Identification Methods pull down, affinity chromatography technology, x-ray crystallography, cross-linking study, light scattering, molecular sieving
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains HDAC4_Gln~HDAC4_Gln, Hist_deacetyl~Hist_deacetyl
Common GO terms GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0004407 - histone deacetylase activity
and 37 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 1084
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024