HitPredict

Interactor 1: HDAC4 (P56524)
Histone deacetylase 4 (HD4) (EC 3.5.1.98)
Gene: HDAC4

Interactor 2: H4 (P62805)
Histone H4
Gene: H4C1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	10220385
Identification Methods	deacetylase assay
Interaction Type	deacetylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1084 Hs			1 103
+	Hs
		918121 HDAC9_HUMAN (25-1025): 0: 797: 56.25		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		918151 HDAC5_HUMAN (1-1084): 0: 785: 55.67		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Mm
		140249 HDAC1_MOUSE (646-1080): 3.14e-163: 492: 21.46		H4_MOUSE (1-103): 1.38e-48: 151: 100.00
+	Hs
		917226 HDAC1_HUMAN (646-1080): 2.95e-163: 492: 21.68		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917682 HDAC2_HUMAN (647-1082): 7.5e-161: 486: 20.97		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Mm
		918237 HDAC2_MOUSE (647-1082): 2.51e-160: 485: 20.97		H4_MOUSE (1-103): 1.38e-48: 151: 100.00
+	Dm
		950398 HDAC1_DROME (646-1081): 7.01e-160: 485: 20.75		H4_DROME (1-103): 4.51e-48: 150: 99.03
+	Hs
		177252 HDAC3_HUMAN (651-1083): 8.19e-150: 455: 20.62		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	At
		886854 HDA6_ARATH (635-1077): 4.47e-149: 455: 19.44		H4_ARATH (1-103): 3.47e-48: 150: 98.06
+	Sc
		356336 RPD3_YEAST (637-1078): 4.15e-156: 472: 22.37		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Sc
		356643 HDA1_YEAST (628-1045): 2.65e-146: 456: 35.99		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Hs
		918077 HDAC6_HUMAN (574-1040): 2.26e-108: 368: 32.62		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917872 HDAC8_HUMAN (669-962): 5.23e-24: 107: 27.22		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Sc
		356604 HOS2_YEAST (636-958): 3.34e-25: 112: 28.01		H4_YEAST (18-103): 6.13e-41: 132: 90.70